黄卫卫，孔俐，江冬莲，张泓，周小红，张力华，程凯.阿尔茨海默病的康复治疗[J].中华物理医学与康复杂志,2004,(1):
扫码阅读全文
|
| 阿尔茨海默病的康复治疗 |
|
| |
| DOI： |
| 中文关键词: 阿尔茨海默病 康复 盐酸多奈哌齐 |
| 英文关键词: Alzheimer's disease Rehabilitation treatment Donepezil |
| 基金项目: |
|
| 摘要点击次数: 1197 |
| 全文下载次数: 1592 |
| 中文摘要: |
| 目的探讨康复治疗对阿尔茨海默病（AD）患者的有效性。 方法将63例轻、中度AD患者分成2组进行为期8周的临床治疗，即康复组（29例）进行康复治疗，药物组（34例）应用盐酸多奈哌齐进行药物治疗。应用简易智能精神状态检查量表（MMSE）、AD评定量表（ADAS）及Blessed-Roth痴呆量表判定疗效。 结果康复组患者的日常生活自理能力改善（P<0.05）；药物组的认知功能：MMSE较治疗前提高3.9分（P<0.05），ADAS认知部分(ADAS-cog)改善4.8分(P<0.05)，日常生活自理能力无明显变化，其中2例(5.88%)出现轻度副作用；2组经治疗后的MMSE、ADAS认知部分和Blessed-Roth评分进行比较，差异均有显著性意义（P<0.05）。 结论康复治疗能改善AD患者的日常生活自理能力；盐酸多奈哌齐可改善AD患者的认知功能，减轻痴呆的病情；整个治疗过程安全性好；康复干预应采取综合措施。 |
| 英文摘要: |
| Objective To investigate the effect of rehabilitation intervention in treatment of Alzheimer's disease. MethodsSixty-three patients with AD were divided into two groups: Group A(n=29)underwent rehabilitation treatment and group B(n=34) was administered with oral intake of Donepezil. The efficacy was evaluated before and after treatment by the Mini-Mental State Examination (MMSE), the Alzheimer's Disease Assessment Scale-Cognition (ADAS-cog) and Blessed-Roth Scale. ResultsAfter 8 weeks of rehabilitation treatment, the patients' ability in daily life in group A was improved as indicated by the decrease of Blessed-Roth Scores (P<0.05), while the cognition of AD patients was increased（P<0.05）,as indicated by MMSE score and the cognitive portion of ADAS scores (P<0.05). There were significant differences between group A and group B in MMSE,ADAS-cog and Blessed-Roth Scale scores. Mild side effect was observed in 2 patients(5.88%). ConclusionRehabilitation therapy could improve the ability of daily life of AD patients, while Donepezil was effective in improve the cognition of AD patients. Comprehensive interventions should be implemented for the AD patients. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
