郑晓珂、王利娟、张红巧.冷热物理治疗对乳腺癌患者术后肺转移及外周血免疫应答的影响[J].中华物理医学与康复杂志,2016,38(5):375-379
扫码阅读全文
|
| 冷热物理治疗对乳腺癌患者术后肺转移及外周血免疫应答的影响 |
|
| |
| DOI： |
| 中文关键词: 冷热物理治疗 乳腺癌 免疫响应 肺转移 |
| 英文关键词: Cooling Heating Breast cancer Immune response Lungs Metastasis |
| 基金项目: |
|
| 摘要点击次数: 2142 |
| 全文下载次数: 3191 |
| 中文摘要: |
| 目的 观察冷热物理治疗对乳腺癌患者术后肺转移及外周血免疫应答的影响。 方法 采用随机数字表法将124例乳腺癌患者分为冷热治疗组及常规治疗组，每组62例。2组患者均给予常规手术切除肿瘤，冷热治疗组患者于术前辅以肿瘤冷热物理治疗。于治疗后观察对比2组患者疗效及生活精神状态；并通过胸部CT法检测对比术后2组患者肺肿瘤转移结节面积；利用流式细胞技术检测治疗后2组患者外周血中免疫细胞变化情况。 结果 治疗后冷热治疗组患者缓解率（54.8%）、生活精神状态KPS评分［（87±12）分］、肺肿瘤转移结节面积［（2.24±0.78）cm2］等均显著优于常规治疗组水平，组间差异均具有统计学意义（P<0.05）。在治疗结束后12周时，常规治疗组患者外周血中骨髓来源抑制性细胞（MDSCs）百分比高达72.5%，CD4+和CD8+ T细胞则分别达2.2%和1.8%；而冷热治疗组患者MDSCs百分比为5.3%，CD4+和CD8+ T细胞百分比分别为26.7%和13.9%，与常规治疗组间差异均具有统计学意义（P<0.05）。 结论 于肿瘤切除手术前辅以冷热物理治疗可有效抑制乳腺癌患者肺转移，提高患者康复疗效及生活精神状态，其治疗机制可能与冷热物理治疗能调控机体免疫抑制微环境、刺激全身性抗肿瘤免疫响应有关。 |
| 英文摘要: |
| Objective To study the effect of cold and heat treatment on metastasis and the peripheral blood immune response in patients with breast cancer. Methods A total of 124 breast cancer patients were randomly divided into a hot and cold therapy group and a control group, each of 62. Both groups were given conventional surgical resections, and the hot and cold therapy group was given cooling and heating physical therapy for one month before the operation. The efficacy of the treatment and the patients′ spiritual state were compared after the treatment. The effect on lung metastases was evaluated using tomographic images of the chest, and the changes in immune cell levels in the peripheral blood were detected using flow cytometry. Results After the treatment, the remission rate (54.8%), spiritual life ratings on the Karnofsky scale and the area of lung cancer nodule transfer were significantly better in the hot and cold therapy group than in the control group. Twelve weeks after the treatment, the percentage of MDSCs in the control group patients was 72.5%, significantly higher than the 5.3% of the therapy group. The CD4+ and CD8+ T cells were 2.2% and 1.8%, significantly lower than the 26.7% and 13.9% of the control group. Conclusion Cold and hot therapy before a mastectomy can effectively inhibit the metastasis of breast cancer and promote patients′ physical rehabilitation and spiritual life. It may regulate the microenvironment of their immunosuppression and stimulate antitumor immunity. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
