| Objective To investigate the effects of high power electromagnetic pulse field on pathological changes in the liver of mice. MethodsTwo hundred and four male Kunming mice were divided into a control group and an irradiation group, which was subdivided into 8×103V/m irradiation group, 2×104V/m irradiation group and 6×104V/m irradiation group according to the irradiation dosage. The mice in control group were given no irradiation. The mice in irradiation groups were irradiated with different dosages of high power electromagnetic pulse（EMP）respectively. Pathological changes of liver of the rats in respective irradiation groups were investigated at 6h, 1d, 3d, 7d, 14d, 1 month, 3 months, 6 months, 9 months and 12 months after irradiation,and compared with the control group at 14d, 3 months, 6 months, and 12 months after irradiation. ResultsPathological changes in the liver of mice developed progressively after irradiation. The degeneration of liver parenchymal cells were mainly observed at the early stage (6h~3d), the necrosis of hepatocytes were serious at the medium-to-late stage (7d~1 months), and at the late stage (3~12 months) the hyperplasia was active, even atypical hyperplasia and neoplasm can be found. ConclusionThe high power electromagnetic irradiation has injurious effect on liver of mice, especially on the liver parenchymal cells. |
