吴军发，吴毅，胡永善，姜从玉，杨晓冰，白玉龙.运动对OLETF大鼠血清肿瘤坏死因子的影响[J].中华物理医学与康复杂志,2003,(3):.-
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| 运动对OLETF大鼠血清肿瘤坏死因子的影响 |
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| DOI： |
| 中文关键词: 运动 OLETF大鼠 肿瘤坏死因子-α 胰岛素抵抗 |
| 英文关键词: Exercise OLETF rat Tumor necrosis factor-α Insulin resistance |
| 基金项目:国家自然科学基金资助项目（No. 39970841）；美国中华医学基金（CMB）资助项目（No. 98-676） |
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| 中文摘要: |
| 目的研究运动及高脂饮食对OLETF大鼠血清肿瘤坏死因子-α（TNF-α）浓度的影响，探讨TNF-α在运动改善机体胰岛素敏感性中所起的作用。 方法对40只自发发病的2型糖尿病模型——OLETF大鼠和15只LETO大鼠进行9周的运动和高脂饮食干预， 9周后用放射免疫法测定每只大鼠血清中TNF-α的浓度。 结果基础饲料饲养的OLETF大鼠非运动组和运动组TNF-α浓度分别为（0.406±0.083）ng/ml和（0.574±0.116）ng/ml；高脂饲料饲养的OLETF大鼠非运动组和运动组TNF-α浓度分别为（0.407±0.097）ng/ml和（0.513±0.098）ng/ml；而基础饲料饲养的LETO大鼠非运动组和运动组TNF-α浓度分别为（0.387±0.087）ng/ml和（0.382±0.077）ng/ml；OLETF大鼠TNF-α浓度运动组明显高于其相对应的非运动组（P<0.01），运动组和非运动组LETO大鼠TNF-α浓度没有明显的差别。 结论运动能使OLETF大鼠TNF-α浓度增加，而对LETO大鼠TNF-α浓度没有明显影响；高脂饮食对OLETF大鼠TNF-α浓度没有明显影响。 |
| 英文摘要: |
| Objective To investigate the effect of exercise and high-fat diet on OLETF rats serum concentration of TNF-α and the mechanism of exercise enhancing insulin sensitivity. MethodsOLETF rat is a spontaneously diabetic animal model and LETO rat a non-diabetic control model. After 9 weeks of exercise and high-fat diet on 40 OLETF rats and 15 LETO rats, the serum concentration of TNF-α was measured by means of radioactive-immune kit. ResultsThe serum level of TNF-α of non-exercise and exercise OLETF rats fed by chow were（0.406±0.083）ng/ml and（0.574±0.116）ng/ml, respectively; for the OLETF rats fed by high-fat diet, the serum level of TNF-α of those intervened with non-exercise and exercise were（0.407±0.097）ng/ml and （0.513±0.098）ng/ml , respectively. For the LETO rats, the serum concentration of TNF-α of those with non-exercise and exercise were（0.387±0.087）ng/ml and（0.382±0.077）ng/ml, respectively. The serum level of TNF-α in exercise OLETF rats were significantly higher than that in non-exercise OLETF rats（P<0.01）, however, the difference of the serum level of TNF-α between the non-exercise and exercise LETO rats was not statistically significant. ConclusionExercise can increase the level of serum TNF-α in OLETF rats; and high-fat diet had not changed significantly the serum concentration of TNF-α in OLETF rats. |
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