吴军发，吴毅，胡永善，孙莉敏，姜从玉.运动对2型糖尿病大鼠血清瘦素水平的影响[J].中华物理医学与康复杂志,2003,(1):。-
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| 运动对2型糖尿病大鼠血清瘦素水平的影响 |
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| DOI： |
| 中文关键词: 运动 糖尿病，非胰岛素依赖型 瘦素 |
| 英文关键词: Exercise Diabetes mellitus, non insulin dependent Leptin |
| 基金项目:国家自然科学基金资助项目（No. 39970841）；美国中华医学基金（CMB）资助项目（No. 98－676） |
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| 中文摘要: |
| 目的研究运动及高脂饮食对2型糖尿病模型—OLETF大鼠血清瘦素（Leptin）水平的影响，探讨Leptin与2型糖尿病发病之间的关系，以及Leptin在运动改善机体胰岛素敏感性中所起的作用。 方法对40只自发发病的2型糖尿病模型—OLETF大鼠和15只LETO大鼠进行为期9周的运动和高脂饮食干预， 9周后用放射免疫法测定每只大鼠血清中Leptin浓度。 结果采用基础饲料饲养的OLETF大鼠非运动组和运动组血清Leptin浓度分别为（6.50±0.75）ng/ml和（1.28±0.15）ng/ml；采用高脂饲料饲养的OLETF大鼠非运动组和运动组血清Leptin浓度分别为（6.83±0.68）ng/ml和（1.65±0.37）ng/ml；而采用基础饲料饲养的LETO大鼠非运动组和运动组血清Leptin浓度分别为（1.02±0.13）ng/ml和（1.20±0.14）ng/ml；OLETF大鼠运动组血清Leptin浓度明显低于其相对应的非运动组（P<0.05），两个OLETF非运动组大鼠的血清Leptin浓度均明显高于LETO大鼠非运动组（P<0.05），而LETO大鼠血清Leptin浓度运动组和非运动组之间没有明显的差别，另高脂饮食对OLETF大鼠Leptin血清浓度没有明显影响。 结论Leptin可能是具有胰岛素抵抗机制的OLETF大鼠维持机体能量代谢平衡的一种调节因子；运动能够改善OLETF大鼠胰岛素敏感性，与血清Leptin的浓度变化没有直接关系。 |
| 英文摘要: |
| ObjectiveTo investigate the role of Leptin in the development of non-insulin-dependent diabetes mellitus and enhancement of body sensitivity to insulin after exercise. Methods Forty OLETF rats and fifteen LETO rats were used in this experimental study and subjected to different diet and exercise regimes. The serum concentration of Leptin was measured by means of radio-immunity kit at 9 weeks later, a comparison of the results was made among the animals. Results The serum Leptin level of non-exercise and exercise OLETF groups fed by ordinary chow was（6.50±0.75） ng/ml and （1.28±0.15）ng/ml, respectively. In those fed by high-fat diet, the serum Leptin level of non-exercise and exercise OLETF groups was（6.83±0.68）ng/ml and （1.65±0.37）ng/ml, respectively. As to the LETO rats, the serum concentration of Leptin in non-exercise and exercise groups was（1.02±0.13）ng/ml and （1.23±0.14）ng/ml, respectively. The serum Leptin level in rats in the exercise OLETF group was significantly lower than that of the non-exercise OLETF group（P<0.01）, but the difference of the serum Leptin level between non-exercise and exercise LETO group was not significant. Conclusion Serum Leptin in OLETF rats may serve as a regulator in maintaining the balance of energy metabolism; exercise can improve the insulin sensitivity in OLETF rats, irrespective of the changes of plasma Leptin level. |
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