陈祢,王俭,王宝兰,等.右侧正中神经电刺激促醒疗法对健康人脑功能影响的fMRI研究[J].中华物理医学与康复杂志,2019,41(2):91-95
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| 右侧正中神经电刺激促醒疗法对健康人脑功能影响的fMRI研究 |
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| DOI：DOI:10.3760/cma.j.issn.0254-1424.2019.02.003 |
| 中文关键词: 右侧正中神经电刺激 促醒 功能磁共振成像 |
| 英文关键词: Right median nerve Electrical stimulation Functional magnetic resonance imaging |
| 基金项目:新疆医科大学第一附属医院自然科学基金项目（2013ZRQN02）；新疆维吾尔自治区自然科学基金项目（2015211C036） |
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| 中文摘要: |
| 目的 探讨右侧正中神经电刺激（RMNS）促醒疗法对健康人脑功能的影响。 方法 选取28例健康志愿者作为受试者，将RMNS促醒治疗模式作为任务刺激，采用Block实验设计，给予受试者30 s刺激-30 s休息共重复6次，并同步采用大脑功能磁共振成像(fMRI)技术进行成像扫描。使用SPM 12软件进行统计处理时将同一受试者刺激状态与静息状态的脑功能成像互为对照，分析其脑区激活情况。 结果 fMRI检查显示，RMNS促醒治疗模式下健康人脑正激活区主要集中在左侧初级运动皮质(M1)、皮质运动前区(PMC)，双侧初级体感皮质(S1）、双侧次级体感皮质(S2)及左侧岛叶。与静息态相比，RMNS促醒刺激模式下上述激活脑区BOLD信号强度变化较大，T>5.84，P<0.05（FWE校正）。 结论 右侧正中神经电刺激促醒治疗能通过激活右手运动及感觉功能相关脑区，兴奋局部大脑皮质，产生一定促醒效应。 |
| 英文摘要: |
| Objective To explore the effect of right median nerve stimulation (RMNS) on brain function in healthy subjects . Methods Twenty-eight healthy volunteers were selected as the study′s subjects. RMNS was administered as a task stimulation in a wake-up therapy mode. The subjects were given 30 seconds of stimulation followed by 30 seconds of rest, repeated for 6 times as the block experiment designed, and functional magnetic resonance imaging (fMRI) was performed simultaneously with the task stimulation . The brain activation was analyzed using SPM 12 software. Results The fMRI showed that RMNS activated primarily the left M1, the premotor cortex (PMC), the bilateral primary and secondary somatosensory cortexes (S1 and S2), and the left insular lobe. Compared with the resting state, the intensity of BOLD signal in the above activated brain areas changed significantly in RMNS wake-up stimulation mode. Conclusion Stimulation of the right median nerve can stimulate the local cerebral cortex and produce a certain wake-up effect by activating the right brain areas related to the motor and sensory functioning of the hand. |
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