韩丽莎，韩利，马玉亭，王芳.旋磁场对大鼠实验性缺血心肌保护作用的机制研究[J].中华物理医学与康复杂志,2003,(11):.-
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| 旋磁场对大鼠实验性缺血心肌保护作用的机制研究 |
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| DOI： |
| 中文关键词: 旋磁场 垂体后叶素 心肌缺血 大鼠 |
| 英文关键词: Electromagnetic field Pituitrin Myocardial ischemia Rats |
| 基金项目: |
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| 摘要点击次数: 2041 |
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| 中文摘要: |
| 目的观察旋磁场对垂体后叶素致心肌缺血的保护作用并探讨其机制。 方法大鼠30只，采用静脉注射垂体后叶素（2 U/kg体重）造成急性心肌缺血动物模型，经旋磁场作用后，观察心电图ST段升高幅度、T波振幅；血清一氧化氮（NO）含量；血清和心肌超氧化物歧化酶（SOD）活力和脂质过氧化物丙二醛（MDA）含量的变化。 结果40 mT旋磁场作用30 min，能减轻垂体后叶素引起的大鼠心肌缺血时血清及心肌SOD的活力降低（0.1＞P＞0.05，P＜0.01）；抑制MDA的生成（P＜0．05）；增加血清NO含量，且在30 min时更明显（P＜0.01）；心电图中ST段升高幅度、T波振幅均较缺血组显著降低（P＜0．05）。 结论在适当场强作用下，旋磁场通过增加血清和心肌SOD活力、降低MDA含量，增加血清NO含量对大鼠实验性缺血心肌发挥保护作用。 |
| 英文摘要: |
| Objective To study the effect of rotary magnetic field on experimental myocardial ischemia caused by Pituitrin (Pit) injection in rats. MethodsThirty rats with experimental myocardial ischemia induced by intravenous injection of Pit (2U/kg) were divided into three groups: control group, ischemia group, rotary magnetic field group. The ST=segment elevated amplitude, T=wave amplitude of ECG, serum NO content, SOD activity and MAD content in the three groups were observed and compared. ResultsThe 30 mT rotary magentic field for 30 min significantly increased SOD activity （P＜0.01） and decreased MDA production （P＜0.05） in rats with experimental myocardial ischemia caused by intravenous injection of Pit. Meanwhile, the NO content was increased significantly in 30 min (P＜0.01). The ECG parameters including ST=segment elevation, T=wave amplitude were improved in rotary magnetic field group as compared with those of the ischemic group (P＜0.05). ConclusionThe proper intensity of rotary magnetic field has protective effect on experimental myocardial ischemia by increasing NO content, SOD activity and decreasing MDA content. |
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