谭永霞，李玲，陈景藻.8 Hz次声对大鼠海马和颞叶皮层5-HTR表达的影响[J].中华物理医学与康复杂志,2004,(10):
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| 8 Hz次声对大鼠海马和颞叶皮层5-HTR表达的影响 |
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| DOI： |
| 中文关键词: 次声 大鼠 海马 颞叶皮层 5-羟色胺受体 |
| 英文关键词: Infrasound Rats Hippocampus Temporal cortex 5-HTR |
| 基金项目:全军医学科学技术研究“十五”计划指令性课题（No.01L071） |
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| 中文摘要: |
| 目的研究90 dB/8 Hz，100 dB/8 Hz，130 dB/8 Hz的次声对SD大鼠海马及颞叶皮层5-羟色胺受体（5-HTR）表达的影响。 方法大鼠分别接受90 dB/8 Hz，100 dB/8 Hz或130 dB/8 Hz的次声作用1，7，14，21，28，35或42 d，每天2 h；于相应时间点取大鼠脑组织进行5-HTR免疫组织化学染色，光学显微镜下观察海马及颞叶皮层5-HTR表达的变化。 结果次声作用组大鼠脑组织海马及颞叶皮层5-HTR表达均较对照组减少，90 dB组、100 dB组以35 d减少最为明显，而130 dB组以28 d最为明显（均P<0.01），且35 d时，100 dB组的表达减少较90 dB组明显，各组阳性表达在此后均有所回升。 结论90 dB/8 Hz，100 dB/8 Hz和130 dB/8 Hz次声可引起大鼠海马及颞叶皮层5-HTR表达减少，其变化规律与次声作用参数有关，相同作用时间下，130 dB组的变化较100 dB组及90 dB组的变化明显。 |
| 英文摘要: |
| Objective To study the effect of 8Hz infrasound on the expression of 5-HTR of hippocampus and temporal cortex in rats. MethodsSD rats were exposed to 8Hz， 90dB,100dB or 130dB infrasound, respectively for 2 hours daily. Then the rats brains were taken and given stained immunohistochemically for （5-hydroxy tryptamine receptor，5-HTR）. The content of 5-HTR in hippocampus and temporal cortex were detected under an optical microscope. ResultsThe animals in the infrasound groups had less expression of 5-HTR in hippocampus and temporal cortex, and the least were at the 35th day for 90dB group and 100dB group and the 28th day for 130dB group (P<0.01), and on the 35th day, 100dB group had less expression than that of 90dB group. Then the expression of 5-HTR had an increase in each group. ConclusionThe decreased expression of 5-HTR of hippocampus and temporal cortex in rats could result from exposure to infrasound of 8Hz.The changes were related to the parameter of infrasound. The 130dB group had greater change of 5-HTR in hippocampus and temporal cortex than that of 100dB and 90dB groups after exposure to infrasound for the same period of time. |
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