杜宝琮，杜威，刘烁，金妍.超声-中频电疗的镇痛效果及其机制的实验研究[J].中华物理医学与康复杂志,2004,(8):
扫码阅读全文
|
| 超声-中频电疗的镇痛效果及其机制的实验研究 |
|
| |
| DOI： |
| 中文关键词: 超声-中频电治疗 痛阈 脑啡肽 |
| 英文关键词: Ultrasound-medium frequency electrotherapy Pain threshold Enkaphalin |
| 基金项目: |
|
| 摘要点击次数: 925 |
| 全文下载次数: 1223 |
| 中文摘要: |
| 目的观察超声-中频电治疗的镇痛作用及其对大鼠脑啡肽水平的影响，探讨其镇痛作用与脑啡肽神经化学物质变化间的相关性。 方法对大鼠经超声-中频电作用后的疼痛反应进行定性、定量分析，并通过直线回归方法分析大鼠痛阈值变化与腺垂体、丘脑下部脑啡肽（EK）变化的相关性，探讨其镇痛作用机制。 结果大鼠经超声-中频电单次作用后，其腺垂体及丘脑下部甲硫氨酸脑啡肽（MEK）和亮氨酸脑啡肽（LEK）含量均较治疗前显著升高（均P＜0.05）；MEK组和LEK组大鼠痛阈值变化率分别为265.79%和272.90%，两组间比较，差异无显著性意义；经直线回归分析后发现，超声-中频电对大鼠的镇痛作用与腺垂体MEK含量具有正相关性（r=0.91，P＜0.01）。 结论腺垂体MEK水平升高可能是超声-中频电疗法发挥镇痛作用的重要机制之一。 |
| 英文摘要: |
| Objective To observe the effects of ultrasound-medium frequency electrotherapy on pain and content of enkephalins. MethodsThe pain threshold of the rat was measured before and after the application of ultrasound-medium frequency electrotherapy. The content of met-enkephalin(MEK) and leu-enkephalin(LEK) in the glandula hypophysis and hypothalamus was also measured. A linear regression analysis based on the pain threshold and the content of enkaphalin was conducted to reveal the pain-relieving mechanism of the ultrasound-medium frequency electrotherapy. ResultsThe level of MEK and LEK in the glandula hypophysis and hypothalamus was significantly increased after a single use of ultrasound-medium frequency electrotherapy as compared with that before the treatment (P<0.05). The linear regression indicated a positive relationship between the MEK level in glandula hypophysis and the pain relieving effect. ConclusionThe pain-relieving of ultrasound-medium frequency electrotherapy might be highly correlated with the MEK level of glandula hypophysis. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
