李承晏，李涛，高晓锋，余绍祖.亚低温治疗实验性脑梗死时对心脏的影响[J].中华物理医学与康复杂志,2003,(4):.-
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| 亚低温治疗实验性脑梗死时对心脏的影响 |
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| DOI： |
| 中文关键词: 亚低温 局灶性脑缺血 心肌高能磷酸化合物 心电图 心肌超微结构 |
| 英文关键词: Mild hypothermia Focal brain ischemia Myocardial high-energy phosphate Myocardial ultrastructure |
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| 中文摘要: |
| 目的研究全身亚低温治疗实验性脑梗死时对心脏的影响。 方法58只Wistar大鼠分成对照组（n＝10）、常温组（n＝24）和亚低温组（n＝24），采用线栓法制作大脑中动脉（MCA）梗死模型。监测ECG，测定术后12 h心肌高能磷酸化合物（ATP、ADP、AMP）、能量储备（EC）值和心肌超微结构改变。 结果缺血后12 h时常温组和亚低温组大鼠心肌ATP、ADP、EC均低于对照组（P<0.01），但亚低温组的ATP和EC却高于常温组（P<0.01）；常温组和亚低温组异常ECG发生率无明显差异(P＞0.05)；但亚低温组的心率明显低于常温组（P<0.01），有3只大鼠的心率低于150次/min；超微结构显示常温组和亚低温组心肌均有缺血性损伤，但亚低温组的损伤较常温组轻。 结论全身亚低温治疗实验性脑梗死时能改善心肌的能量储备，减轻脑梗死引起的心肌缺血，不会增加ECG异常的发生率，但可显著减缓心率。 |
| 英文摘要: |
| Objective To investigate the effects of systemic mild hypothermia on heart. MethodsFifty-eight Wistar rats were divided randomly into three groups: control group (n=10), normal thermic group (n=24) and mild hypothermic group (n=24). After the model of middle cerebral artery occlusion (MCAO) was made, electrocardiograph (ECG) was used to monitor the cardiac function of the animals. The changes of myocardial high-energy phosphates (ATP，ADP，AMP) and energy charge (EC) were evaluated after 12 hours of ischemia, and the myocardial ultrastructure observed. ResultsCompared with the control group, the ATP, ADP and EC in the normal thermic group and mild hypothermic group were lower after 12 hours of ischemia (P<0.01), while the ATP, EC in mild hypothermic group were higher than those in normal thermic group (P<0.010). The heart rate of mild hypothermic group was lower than normal thermic group (P<0.01). There was no significant difference between the mild hypothermic and the normal thermic groups with regard to the incidence of abnormal ECG. The ischemic myocardial damage in the rat of mild hypothermic group was milder than that of normal thermic group. ConclusionSystemic mild hypothermia can improve myocardial EC and ameliorate the ischemic myocardial damage, result in no severe electrocardiographic abnormality. Thus it can exert favourable effect for preserving cardiac function in rat after cerebral ischemic injury. |
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