李刚，李六一，宋佳，庞咪，马明明，徐长水，张杰文.重复经颅磁刺激对脑静脉血栓形成后认知功能障碍的影响[J].中华物理医学与康复杂志,2017,39(5):327-331
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| 重复经颅磁刺激对脑静脉血栓形成后认知功能障碍的影响 |
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| 中文关键词: 重复经颅磁刺激 脑静脉血栓形成 认知功能障碍 事件相关电位 |
| 英文关键词: Transcranial magnetic stimulation Cerebral venous thrombosis Cognitive impairment Event-related potentials |
| 基金项目:基金项目：河南省医学科技攻关计划指导性计划项目（201304039）；河南省科技攻关项目（172102310653） |
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| 中文摘要: |
| 目的观察重复经颅磁刺激(rTMS)对脑静脉血栓形成后认知障碍患者认知功能的影响。 方法选取脑静脉血栓形成后认知功能障碍患者43例，采用随机数字表法将其分为rTMS组及对照组。2组患者均给予常规药物治疗及康复训练，rTMS组患者在此基础上辅以rTMS治疗。于治疗前、治疗4周后分别采用蒙特利尔认知评估量表(MoCA)、汉密尔顿抑郁量表（HAMD）、改良Barthel指数（MBI指数）对2组患者进行疗效评定，同时于上述时间点对2组患者进行事件相关电位（ERP）P300检查。 结果治疗后2组患者MoCA、MBI评分均较治疗前增加，HAMD评分较治疗前降低，P300潜伏期均较治疗前缩短，波幅较治疗前升高，差异均具有统计学意义(P<0.05)；并且上述指标（包括MoCA、MBI、HAMD评分及P300潜伏期）均以rTMS组患者的改善幅度较显著，与对照组间差异均具有统计学意义(P<0.05)。 结论在常规干预基础上辅以rTMS治疗，能进一步改善CVT后认知障碍患者认知功能，该联合疗法值得临床推广、应用。 |
| 英文摘要: |
| Objective To explore any effect of repetitive transcranial magnetic stimulation (rTMS) on the cognitive ability of patients suffering from cognitive impairment after cerebral venous thrombosis (CVT). MethodsForty-three CVT patients with cognitive impairment were recruited and randomly assigned into an rTMS group (n=23) or a control group (n=20)．Both groups received routine drug therapy and cognitive function training, while the rTMS group was additionally given rTMS. The treatment lasted 4 weeks. The Montreal cognitive assessment (MoCA), the Hamilton depression scale (HAMD), the modified auditory Barthel Index (MBI) and event-related potential P300 were used to test both groups before and after the treatment． ResultsAfter the treatment the average MoCA and MBI scores of both groups had increased significantly, while their average HAMD scores had decreased significantly compared to before the treatment. For both groups, the P300 latency had shortened significantly and the amplitude increased significantly after the treatment. The improvement in all of these indicators was significantly greater in the rTMS group than in the control group. ConclusionSupplementing drug therapy with rTMS can significantly improve the cognitive ability of CVT patients and is worth applying in clinical practice． |
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