李书林，曾琳，蒋晓江，陈曼娥，廖维宏.大鼠实验性脑出血后F波和脊髓前角血流量的改变[J].中华物理医学与康复杂志,2004,(1):
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| 大鼠实验性脑出血后F波和脊髓前角血流量的改变 |
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| DOI： |
| 中文关键词: 脑出血 F波 血流量 脊髓 |
| 英文关键词: Cerebral hemorrhage F-wave Blood flow Spinal cord |
| 基金项目:第三军医大学课题（No.200037） |
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| 中文摘要: |
| 目的观察实验性大鼠脑内囊出血后脊髓血流量和后肢F波的变化，以探讨实验性脑出血对脊髓功能改变的影响。 方法采用大鼠自体血缓慢注入右侧内囊后肢，制备大鼠脑内囊出血模型。应用电生理学方法检测左、右侧腓肠肌F波的变化，以判断下运动神经元兴奋性改变；同时用氢清除法检测脊髓灰质血流量的改变。 结果大鼠右侧内囊出血后，左侧腓肠肌F波波幅显著高于右侧（P<0.01）；出血后第1天，左侧腓肠肌F波波幅明显升高(P<0.01)，1、2周后波幅升高更为明显。F波的潜伏时也发生了相应的改变，左侧F波潜伏时明显低于右侧(P<0.01)，内囊出血后第1天、1周、2周，F波潜伏时明显低于出血前(P<0.01)。相反，右侧F波波幅及潜伏时与出血前差异无显著性意义(P>0.05)。脊髓腰膨大灰质前角局部血流量在出血后2周内双侧差异无显著性意义（P>0.05）。 结论向大鼠内囊定向性注入自体血可以引起对侧肢体腓肠肌F波的波幅显著升高，同时F波潜伏时明显缩短，表明下运动神经元的兴奋性明显升高，同时脊髓灰质前角血流量双侧并无显著不同，这可能与大鼠脊髓内踏步中枢模式发生器有关。 |
| 英文摘要: |
| Objective To explore the effect of cerebral hemorrhage on the function of spinal cord， through observing the changes of F wave of the hindlimb and blood flow in the spinal cord in rats with experimentally-induced internal capsule hemorrhage. MethodsThe internal capsule hemorrhage model was established by injecting self-body blood into the hindlimb of the right capsule. The changes of F wave in the bilateral gastrocnemius muscles were examined to evaluate the excitability of the motor neurons in the anterior horn. Meanwhile， the blood flow in the gray matter of spinal cord was determined by measuring the hydrogen clearance. ResultsFollowing the right internal capsule-oriented hemorrhage， the amplitude of F wave recorded from the left gastrocnemius muscle increased significantly in the first day after hemorrhage (P<0.01) and increased more obviously after 1， 2 weeks， as compared with that of the right side (P<0.01)， the latencies of F wave were also changed. The latencies of F wave from the left gastrocnemius muscle at 1， 2 weeks after-hemorrhage were significantly decreased in compare with those before hemorrhage， as well as those of the right side(P<0.01). However， the amplitude and the latencies of F wave recorded from the right side were not significantly changed after hemorrhage was induced(P>0.05)，nor was the blood flow of gray matter in the anterior horn of lumbosacral enlargement of the spinal cord within 2 weeks after hemorrhage. ConclusionCerebral hemorrhage caused significant increase of the excitability of the anterior horn motor neurons in the spinal cord， as indicated by the changes of F wave amplitude and latency， but no significant change of the blood flow in the gray matter in the anterior horn was observed. |
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