张文姚，任爱华，于小妹，朱利月，金宏义.运动对老年高血压病患者血流动力学和心血管体液因子的影响[J].中华物理医学与康复杂志,2004,(5):
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| 运动对老年高血压病患者血流动力学和心血管体液因子的影响 |
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| DOI： |
| 中文关键词: 运动 高血压 血流动力学 心血管体液因子 |
| 英文关键词: Exercise Hypertention Hemodynamics Cardiovascular humoral factor |
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| 摘要点击次数: 917 |
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| 中文摘要: |
| 目的探讨运动对老年高血压病患者血流动力学和心血管体液因子的影响。 方法高血压组为2~3级老年原发性高血压患者34例（药物控制），正常老年对照组31例，作自感劳累分级法（RPE）11~13级疲劳程度的症状限制性运动平板试验（改良的Bruce方案），试验前3 min、后3 min抽静脉血检测，观察运动过程的心率、血压、运动当量、运动时间及运动前、后的一氧化氮(NO)、内皮素（ET1）、血管紧张素Ⅱ（AngⅡ）、心房肽（ANF）。 结果高血压组与对照组比较，平板运动前、运动峰时、恢复期3 min的心率、收缩压、舒张压及总的运动时间、峰时的运动当量，均P>0.05,差异无显著性意义；运动后高血压组NO上升48.7%，对照组上升52.0%，均P<0.05，差异有显著性意义；高血压组ANF运动前比对照组高22.0%，P=0.006；2组运动前、后差值比较，NO、ET1、AngⅡ、ANF均P>0.05。运动前收缩压与运动峰时、运动后收缩压正相关（r=0.648，0.630，P<0.001）；运动前舒张压与运动峰时、运动后舒张压呈正相关（r=0.359，0.520，P<0.001）；年龄与平板运动当量呈负相关（r=0.655,P<0.001）。 结论老年高血压患者在药物控制下参加轻度疲劳程度的运动(相当于8运动当量)过程中，其心率、血压的升高与正常对照组相似；血液中NO的变化有益于高血压病的治疗，短时间内未见ET1、AngⅡ和ANF水平的明显改变。 |
| 英文摘要: |
| Objective To study the effects of exercise on hemodynamic parameters and cardiovascular humoral factors in the elderly patients with hypertension. MethodsThe modified Bruce assessment (MBA) was employed in an essential hypertension (EH) group (group 1, n=34) composed by elderly EH patients and a control group (group 2, n=31) composed of normal subjects. Heart rate (HR),systolic and diastolic blood pressure (SBP、DBP), and the quantum and duration of exercise (QE, DE) were explored, while the serum concentrations of nitric oxide (NO), endothelin 1(ET1), atrial natriuretic factor (ANF) and AngiotensinⅡ(AngⅡ) were measured at 3 min before and after treatment. ResultsThere were no significant differences between groups 1 and 2 with regard to HR, SBP, DBP, total DE and peak QE before and after treatment, in addition, at the peak of exercise (P<0.05, respectively). After exercise, the concentrations of NO in groups 1 and 2 were significantly increased by 48.7% and 52.0%, respectively. Compared with that in group 2, the concentration of ANF in group1 was higher by 22.0% (P=0.006); There were no significant differences between the concentrations of NO, ET1, AngⅡ and ANF before and after treatment in group 2 (P>0.05). Pretreatment SBP and DBP were significantly and positively correlated with those at the peak of and after treatment (r=0.648,0.630,P<0.001; r=0.359,0.520, P<0.001, respectively). QE was negatively correlated with age (r=0.655,P<0.001). ConclusionThe increase of HR, BP in elderly EH patients with drug therapies and low-grade exercise (8 MET) is similar to that of the healthy elderly. The changes of the concentration of NO may contribute to the alleviation of EH, and the changes of ET、AngⅡ and ANF were not obvious in short term. |
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