叶欣，林佛财，黄丽葵，谢增东，吴榕，沈庆煜，唐亚梅.鼠神经生长因子治疗鼻咽癌放疗后吞咽困难的疗效观察[J].中华物理医学与康复杂志,2016,38(1):29-33
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| 鼠神经生长因子治疗鼻咽癌放疗后吞咽困难的疗效观察 |
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| DOI： |
| 中文关键词: 鼻咽癌 放射治疗 吞咽困难 鼠神经生长因子 电视透视吞咽功能检查 |
| 英文关键词: Nasopharyngeal carcinoma Radiotherapy Dysphagia Nerve growth factors Videofluoroscopy Swallowing |
| 基金项目:国家自然科学基金资助项目（81272576, 81471249）；广东省自然科学基金（2014A030313120）；教育部新世纪优秀人才（NCET-13-0612） |
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| 中文摘要: |
| 目的探讨鼠神经生长因子治疗鼻咽癌放疗后吞咽困难的疗效及安全性。 方法采用随机数字表法将58例鼻咽癌放疗后出现吞咽困难患者分成对照组及观察组，对照组给予常规治疗，观察组则在常规治疗基础上辅以鼠神经生长因子肌肉注射，每天注射1次，持续治疗4周。于治疗前、治疗4周时采用洼田饮水试验、电视透视吞咽功能检查（VFSS）及简版世界卫生组织生存质量测定量表（WHOQOL-BREF）对2组患者吞咽功能、生活质量进行评定。 结果经4周治疗后，发现观察组患者饮水试验分级改善值［（1.0±0.8）级］明显优于对照组（P<0.05）；观察组患者在吞咽流质食物时其Rosenbek评分改善值［（1.8±3.1）分］亦显著优于对照组（P<0.05）；观察组患者在吞咽流质、半流质、固体食物时其VDS评分改善值分别为（7.8±7.1）分、（6.2±6.6）分、（9.0±8.7）分，以上指标与对照组间差异均具有统计学意义（P<0.05）；另外观察组患者在吞咽流质、半流质、固体食物时其口腔通过时间(OTT)、咽部通过时间(PTT)及咽部延迟时间(PDT)均较对照组有不同程度改善，并且观察组患者生活质量评分亦显著优于对照组(P<0.05)。 结论鼠神经生长因子治疗放射性后组颅神经损伤具有较好疗效，且治疗过程中未发现与药物相关的明显不良反应。 |
| 英文摘要: |
| Objective To evaluate the effectiveness and safety of mouse nerve growth factor in treating dysphagia in patients with nasopharyngeal carcinoma after radiotherapy. Methods Fifty-eight post-radiotherapy nasopharyngeal carcinoma patients with dysphagia were randomly divided into an observation group and a control group. Both groups received routine treatment, but the observation group was additionally injected with mouse nerve growth factor intramuscularly every day for four weeks. Before and after the 4 weeks of treatment, both groups were evaluated using Kubota′s water drinking test, videofluoroscopy and the brief version of the WHO′s Quality of Life scale. ResultsAfter 4 weeks, the patients in the observation group displayed significantly greater improvement in swallowing compared with the control group. There was a significant difference in the groups′ average scores on the drinking water test and in the videofluoroscopy results. Moreover, the patients in the observation group had significantly higher quality of life scores than those in the control group, on average. ConclusionsMouse nerve growth factor may have a rapid and safe therapeutic effect on dysphagia induced by radiation. No obvious adverse reactions were observed. |
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