刘志超，李承晏，董红娟，毛善平.亚低温对大鼠急性脑梗死后脑组织内Ca2+、Mg2+、EAA及血浆ET变化的影响[J].中华物理医学与康复杂志,2003,(11):.-
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| 亚低温对大鼠急性脑梗死后脑组织内Ca2+、Mg2+、EAA及血浆ET变化的影响 |
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| DOI： |
| 中文关键词: 脑梗死 亚低温 Ca2+ Mg2+ 兴奋性氨基酸 内皮素 |
| 英文关键词: Cerebral infarction Mild hypothermia Ca2+ Mg2+ EAA ET |
| 基金项目:湖北省科委科研基金资助项目（No.952P1902） |
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| 中文摘要: |
| 目的探讨亚低温对大鼠急性脑梗死后脑组织内Ca2+、Mg2+、兴奋性氨基酸（EAA）及血浆内皮素（ET）变化的影响及意义。 方法将48只SD大鼠随机分为亚低温组及对照组，各组再分为4个亚组，每亚组6只，应用改良线拴法制备大鼠大脑中动脉梗死模型；亚低温组大鼠给予亚低温治疗，而对照组不作亚低温处理。分别于缺血后1 h、2 h、4 h、8 h处死1亚组，检测缺血区脑组织内Ca2+、Mg2+、EAA及血浆ET含量。 结果亚低温组大鼠缺血区脑组织内Ca2+、Mg2+、EAA及血浆ET含量随着缺血时间的延长仅轻度升高，Mg2+含量的下降也不明显，与对照组同时段比较差异有显著性（P<0.01）。 结论亚低温能明显阻止实验大鼠脑缺血后缺血区脑组织内损伤性因子Ca2+、EAA和ET含量的增高及保护性因子Mg2+的下降，具有脑保护作用。 |
| 英文摘要: |
| Objective To investigate the effect of mild hypothermia on the content of Ca2+、Mg2+、EAA in rat brain tissue and ET in plasma after acute cerebral infarction. MethodsForty=eight Sprague=Dawley rats were randomly assigned into trial group and control group. Using the method of reformed line=thrombosis,the cerebral infarction models were established. The rats in the trial=group were cooled by mild hypothermia for half an hour, while those in the control group were subjected to no disposal. Every group was divided into 4 sub=groups according to the post=infarction disposal time. Every sub=group was composed of 6 SD rats and killed at the time points of 1 hour,2 hour,4 hour and 8 hour after infarction, respectively. Then the content of Ca2+、Mg2+、EAA in rat brain tissue and ET in plasma were measured. ResultsThe post=infarction content of Ca2+、EAA and ET of trial=group increased mildly and Mg2+ reduced very little. There was a significant statistical difference between the trial group and the control group. Conclusion Mild hypothermia may significantly reverse the increase of the content of Ca2+ and EAA and the fall of Mg2+ and the increment of ET in plasma as well after acute cerebral infarction in experimental animals. So as a result, mild hypothermia possesses protective effect on brain. |
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