谢宁清,龚瑜,章鑫,等.右侧正中神经电刺激促醒模式对健康成年人前额叶皮质调控效应的功能性近红外光谱成像技术研究[J].中华物理医学与康复杂志,2025,47(10):896-900
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| 右侧正中神经电刺激促醒模式对健康成年人前额叶皮质调控效应的功能性近红外光谱成像技术研究 |
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| DOI：10.3760/cma.j.cn421666-20250321-00246 |
| 中文关键词: 右侧正中神经电刺激 功能性近红外光谱成像技术 前额叶皮质 氧合血红蛋白 脱氧血红蛋白 |
| 英文关键词: Right median nerve Electrical stimulation Functional near-infrared spectroscopy Prefrontal cortex Oxyhemoglobin Deoxyhemoglobin |
| 基金项目:国家重点研发计划 (2018YFC2002302) |
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| 中文摘要: |
| 目的 探讨右侧正中神经电刺激（RMNS）促醒模式对健康成年人前额叶皮质的调控效应。 方法 选取23名右利手健康受试者，通过组块设计实施RMNS促醒模式干预，同步采用功能性近红外光谱成像技术（fNIRS）采集前额叶皮质血氧信号。使用NIRS-KIT工具包处理数据，并分析刺激期与静息期的氧合血红蛋白（HbO）、脱氧血红蛋白（HbR）和总血红蛋白（HbT）浓度变化，通过错误发现率（FDR）校正控制多重比较误差。 结果 fNIRS结果显示，在RMNS促醒模式下，健康成年人左侧额极区（通道15）和右侧额极区（通道37/43/48）的HbO信号均存在显著激活（P<0.05）；右侧额极区（通道41）的HbR信号变化存在显著差异（P<0.05）；所有通道的HbT信号变化差异均无统计学意义（P＞0.05）。 结论 RMNS促醒模式能够增强健康成年人前额叶皮质额极亚区的神经代谢活动。 |
| 英文摘要: |
| Objective To explore any effect of electrical stimulation of the right median nerve (RMNS) in modulating arousal patterns in the prefrontal cortex of a healthy adult. Methods Twenty-three right-handed healthy participants received block-designed patterns of RMNS arousal. Functional near-infrared spectroscopy (fNIRS) was used to record any hemodynamic response in their prefrontal cortex. Changes in oxyhemoglobin (HbO), deoxyhemoglobin (HbR), and total hemoglobin (HbT) were analyzed by comparing the levels in stimulation blocks with resting-state periods. Results fNIRS revealed significant activation of HbO signals in the left frontopolar area (channel 15) and the right frontopolar area (channels 37, 43 and 48) following RMNS arousal. There were significant differences in the HbR signals from the right frontopolar area (channel 41). There were, however, no significant differences in the HbT signals across all the measured channels. Conclusion RMNS arousal enhances neurometabolic activity within the frontopolar sub-region of the prefrontal cortex in healthy adults. |
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