张王利,祖翰卿,王晨宇,等.高强度间歇训练对2型糖尿病患者血糖控制及胰腺β细胞功能的影响[J].中华物理医学与康复杂志,2022,44(12):1084-1089
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| 高强度间歇训练对2型糖尿病患者血糖控制及胰腺β细胞功能的影响 |
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| DOI：10.3760/cma.j.issn.0254-1424.2022.12.006 |
| 中文关键词: 高强度间歇训练 2型糖尿病 血糖控制 胰腺β细胞功能 身体成分 |
| 英文关键词: Interval training Diabetes mellitus Glycemic control Pancreatic β-cells Body composition |
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| 中文摘要: |
| 目的 探讨8周高强度间歇训练（HIIT）对2型糖尿病患者血糖控制及胰腺β细胞功能的影响，为优化糖尿病运动干预方案提供参考。 方法 采用随机数字表法将60例无规律运动习惯的2型糖尿病患者分为运动组及对照组，每组30例。2组患者均维持日常生活习惯不变，运动组患者同时采用功率车测功仪进行每周3次、共8周HIIT干预。于干预前、干预8周后采用2 h口服葡萄糖耐量试验（OGTT）检测患者血糖控制及胰腺β细胞功能，采用双能量X射线吸收法检测身体成分变化。 结果 与干预前比较，干预后运动组空腹血糖（FPG）、平均血糖、糖化血红蛋白（HbA1c）、OGTT 2 h末血糖含量、血糖曲线下面积（AUC）均显著减少（P<0.05），稳态模型胰岛素抵抗指数（HOMA-IR）明显降低（P<0.05），稳态模型评估β细胞功能指数（HOMA-%β）及处置指数（DI）均明显升高（P<0.05），腰围和腹部脂肪含量均显著降低（P<0.05），对照组干预后上述各项指标参数均无显著变化（P>0.05）。干预期间运动组有1例患者失访，其训练计划完成率为98.4%，且运动期间及运动后均无明显不良反应事件发生。 结论 8周HIIT干预能改善2型糖尿病患者血糖控制、胰腺β细胞功能并降低腹部脂肪含量，可作为2型糖尿病患者运动康复干预的有效手段。 |
| 英文摘要: |
| Objective To explore any effect of 8 weeks of high-intensity interval training (HIIT) on glycemia and pancreatic β-cell function among persons with type 2 diabetes to provide data for optimizing their exercise protocol. Methods Sixty patients with type 2 diabetes and without a habit of regular exercise were randomly divided into an exercise group (n=30) and a control group (n=30). Both groups maintained their daily living habits, except that the exercise group practiced HIIT on a power vehicle ergometer 3 times a week for 8 weeks. Before and after the intervention, the 2-hour oral glucose tolerance test (OGTT) was conducted to evaluate glycemia and pancreatic β-cell function. Body composition was also detected using dual-energy X-ray absorptiometry. Results After the intervention a significant decrease was observed in the fasting blood glucose, mean blood glucose, glycosylated hemoglobin, blood glucose levels at the end of a 2h OGTT, blood glucose area under the curve and homeostatic model assessment of insulin resistance, as well as waist circumference and abdominal fat content of the exercise group. And there was a significant increase in the homeostatic model assessment of pancreatic β-cell function and disposition index among the exercise group. In the control group no significant differences were observed. Conclusion Eight weeks of HIIT can improve glycemia and pancreatic β-cell function and reduce abdominal fat among persons with type 2 diabetes. It can be used as an effective rehabilitation protocol. |
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