方玉飞,奚宸斌,厉欢松,等.多焦点经颅直流电刺激对健康人群大脑皮质功能的调控作用[J].中华物理医学与康复杂志,2025,47(8):745-753
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| 多焦点经颅直流电刺激对健康人群大脑皮质功能的调控作用 |
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| DOI：10.3760/cma.j.cn421666-20250126-00085 |
| 中文关键词: 大脑皮质 靶向性 多焦点经颅直流电刺激 功能性近红外光谱成像 有限元电场模拟 |
| 英文关键词: Cerebral cortex Targeted stimulation Multifocal cortex stimulation Functional near-infrared spectroscopy Electric field simulation |
| 基金项目:宁波市骨科与运动康复临床医学研究中心（2024L004）；中国博士后科学基金资助项目（2024M761525）；浙江省康复医学会科研专项基金（ZKKY2024012）；宁波市第二医院华美科研基金（2024HMKYA53）；山东省高等学校青创科技支持计划（2024KJD008） |
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| 中文摘要: |
| 目的 探讨多焦点经颅直流电刺激（m-tDCS）兴奋性和抑制性方案对健康人群大脑皮质功能的影响。 方法 选取15名健康受试者，分别采用m-tDCS兴奋性方案和抑制性方案对其目标皮质（C1-C2-FC1-FC2）开展20 min刺激干预。采用有限元电场模拟计算不同刺激方案下的电场分布特征，并利用功能性近红外光谱成像技术（fNIRS）监测受试者目标皮质的氧合血红蛋白（HbO）、脱氧血红蛋白（HbR）、总氧合血红蛋白（THb）水平，并记录干预过程中的不良反应。 结果 m-tDCS兴奋性方案干预下，大脑左、右半球的电场法向分量（En）分别为0.057 V/m、0.058 V/m，平均0.058 V/m；m-tDCS抑制性方案干预下，大脑左、右半球的En分别为-0.057 V/m、-0.058 V/m，平均-0.058 V/m。与m-tDCS兴奋性方案相比较，m-tDCS抑制性方案下FC1、FC2、C2的HbO浓度显著较低（P＜0.05），FC2、C2的THb浓度较低（P<0.05），而HbR浓度比较，差异无统计学意义（P＞0.05）。两种方案干预过程中，部分受试者出现了刺激部位疼痛等不良反应，但程度随刺激时间的延长而逐渐降低。 结论 m-tDCS兴奋性方案和抑制性方案对健康人群的大脑皮质均有一定的调控作用，其中兴奋性方案较抑制性方案更能增强目标皮质的兴奋性。 |
| 英文摘要: |
| Objective To explore any effect of excitatory and inhibitory multi-focal transcranial direct current stimulation (m-tDCS) on cortical functioning in healthy adults. Methods Fifteen healthy participants received 20-minute excitatory and inhibitory episodes of m-tDCS targeting C1-C2-FC1-FC2. Finite element analysis and functional near-infrared spectroscopy were then used to model the normal component of the electric field (En) applied and to monitor the oxygenated hemoglobin (HbO), deoxygenated hemoglobin (HbR), and total hemoglobin (THb) concentrations in the targeted regions during the stimulation. Results The excitatory protocol induced En values of 0.057V/m and 0.058V/m in the left and right hemispheres, respectively, with an average of 0.058V/m, while the inhibitory one evoked corresponding En values of -0.057V/m and -0.058V/m with an average of -0.058V/m. During excitatory m-tDCS, HbO and THb concentrations in the target cortices were higher than in the inhibitory protocol, with significant differences at FC1, FC2, and C2 for HbO, and at FC2 and C2 for THb. However, no significant inter-group differences in HbR concentrations were observed. Moreover, either protocol induced severe adverse reactions including pain, though the pain decreased with prolonged stimulation. Conclusions Both excitatory and inhibitory m-tDCS modulate cortical function among healthy individuals. Excitatory m-tDCS is the more effective in enhancing cortical excitability. |
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