吴明霞,吴值荣,石立业,等.间歇性θ爆发式磁刺激在学龄前孤独症谱系障碍儿童康复中的应用研究[J].中华物理医学与康复杂志,2025,47(6):495-498
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| 间歇性θ爆发式磁刺激在学龄前孤独症谱系障碍儿童康复中的应用研究 |
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| DOI：10.3760/cma.j.cn421666-20241125-00938 |
| 中文关键词: 间歇性θ爆发式磁刺激 学龄前 孤独症谱系障碍 |
| 英文关键词: Intermittent theta burst stimulation Theta burst stimulation Autism spectrum disorder |
| 基金项目:河南省医学科技攻关计划联合共建项目（LHGJ20230570、LHGJ20220752） |
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| 中文摘要: |
| 目的 观察间歇性θ爆发式磁刺激(iTBS)在学龄前孤独症谱系障碍（ASD）儿童康复中的应用效果。 方法 采用随机数字表法将70例学龄前ASD患儿分为对照组和试验组，每组35例。治疗期间，共有9例患儿退出研究，最终对照组纳入30例，试验组纳入31例。2组患儿均给予常规康复训练，试验组在此基础上增加iTBS治疗，对照组同期给予假磁刺激治疗。治疗前及治疗4周后（治疗后），采用语言发育迟缓检查法（简称S-S法）、自闭症治疗评定量表（ATEC）对2组患儿的语言理解能力、表达能力及治疗效果进行评定，记录研究及随访期间的不良反应情况。 结果 与组内治疗前比较，2组患儿治疗后的语言理解及表达能力均有所改善（P＜0.05），ATEC子项评分及总分均降低（P＜0.05）。与对照组比较，试验组患儿治疗后的语言理解及表达能力较好（P＜0.05），ATEC子项评分［语言(9.52±2.58)分、社交(14.32±3.23)分、认知(12.87±2.61)分、行为(21.13±4.23)分］及总分［(57.84±9.03)分］较低（P＜0.05）。试验组1例患儿在iTBS治疗初期出现头皮不适，经心理疏导及后续2次iTBS治疗适应后，未再出现类似症状。 结论 iTBS可有效改善学龄前ASD患儿的语言理解能力、表达能力及临床核心症状，安全性较好。 |
| 英文摘要: |
| Objective To observe the effect of applying intermittent theta burst stimulation (iTBS) in the rehabilitation of preschool children with autism spectrum disorder (ASD). Methods Seventy preschool children with ASD were randomly divided into a control group and an experimental group, each of 35. Both groups were given routine rehabilitation training, while the experimental group was additionally provided with iTBS for 4 weeks. Before and after the treatment, the children′s language comprehension and expression ability were evaluated using the language retardation test and the Autism Treatment Assessment Scale (ATEC). Results The language comprehension and expression of the children in both groups had improved after the treatment, but the children in the experimental group then had better language comprehension and expression abilities. And they scored better on average in the language, social interaction, cognition and behavior sub-sections of the ATEC. Their average total score was also lower. Conclusions iTBS can safely and effectively improve the language comprehension ability and expression of preschool children with ASD. |
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