陈喆思,黄小飞,田恬,等.不同频率的高频重复经颅磁刺激对高原低氧环境下官兵认知功能减退的影响[J].中华物理医学与康复杂志,2025,47(5):393-397
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| 不同频率的高频重复经颅磁刺激对高原低氧环境下官兵认知功能减退的影响 |
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| DOI：10.3760/cma.j.cn421666-20240924-00786 |
| 中文关键词: 重复经颅磁刺激 认知功能 高原低氧 事件相关电位 |
| 英文关键词: Transcranial magnetic stimulation Cognition High-altitude hypoxia Hypoxia Event-related potentials |
| 基金项目:中国人民解放军西部战区总医院院管课题（2021-XZYG-B12） |
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| 中文摘要: |
| 目的 观察不同频率的高频重复经颅磁刺激（rTMS）对高原低氧环境下驻防官兵认知功能减退的影响。 方法 选取高原低氧环境下认知功能减退的驻防官兵60例，按照随机数字表法将其分为15 Hz组、20 Hz组、25 Hz组，每组20例。15 Hz组、20 Hz组、25 Hz组分别接受15 Hz、20 Hz、25 Hz的高频rTMS，共30 d。治疗前、治疗15 d后及30 d后，对3组官兵开展事件相关电位检测，记录失匹配负波(MMN)潜伏期、P300潜伏期，采用蒙特利尔认知评估量表（MoCA）评定认知功能,并分析电生理观察指标与MoCA评分的相关性。 结果 与组内治疗前比较，3组官兵治疗15 d后的MMN潜伏期均缩短（P＜0.05），MoCA总分及记忆子项评分增加（P＜0.05）。3组官兵治疗后不同时间点的P300潜伏期、MoCA除记忆外的其余子项评分组内及组间比较，差异均无统计学意义（P＞0.05）。15 Hz组、20 Hz组、25 Hz组治疗15 d后的MMN潜伏期，与MoCA记忆子项评分均呈负相关（r=-0.54，P=0.01；r=-0.49，P=0.02；r=-0.44，P=0.04）。 结论 高频rTMS可以有效改善高原低氧环境下官兵的认知功能减退现象，尤其是记忆功能，但疗效存在瓶颈。15 Hz、20 Hz、25 Hz的高频rTMS对认知功能减退的干预效果无显著差异。 |
| 英文摘要: |
| Objective To observe the effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) at different frequencies on cognitive impairment due to high-altitude hypoxia. Methods Sixty officers and soldiers displaying cognitive impairment in a hypoxic high-altitude environment were randomly divided into 15Hz, 20Hz and 25Hz groups, each of 20. They were given rTMS at those frequencies for 30 days. Before the stimulation and after 15 and 30 days, event-related potentials, latencies of mismatched negativity (MMN) and P300 signals were recorded. The participants′ cognition was also evaluated using the Montreal Cognitive Assessment Scale (MoCA). Correlation between the electrophysiological indexes and the MoCA scores was computed. Results After 15 days, all had shorter MMN latencies, higher total MoCA scores and better memory scores. The only significant difference among the three groups was in the average memory scores. After 15 days, MMN latency was significantly negatively correlated with the memory scores in all three groups (r=0.44 to -0.54). Conclusions rTMS at frequencies above 15Hz can effectively relieve cognitive impairment, especially memory dysfunction, resulting from high-altitude hypoxia. |
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