尹汉逵,王中莉,曾明,等.短链脂肪酸与缺血性脑卒中患者日常生活活动能力的相关性研究[J].中华物理医学与康复杂志,2024,46(7):631-634
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| 短链脂肪酸与缺血性脑卒中患者日常生活活动能力的相关性研究 |
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| DOI：10.3760/cma.j.issn.0254-1424.2024.07.010 |
| 中文关键词: 缺血性脑卒中 日常生活活动能力 短链脂肪酸 丁酸 |
| 英文关键词: Ischemia Stroke Activities of daily living Short-chain fatty acids Butyric acid Propionic acid |
| 基金项目:浙江省医药卫生科技临床研究应用项目（2022KY1252）；浙江省医药卫生科技临床研究应用项目（2022KY383）；浙江省医药卫生科技临床研究应用项目（2022KY378）；浙江省医药卫生科技临床研究应用项目（2022KY1254） |
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| 中文摘要: |
| 目的 探讨短链脂肪酸（SCFAs）与缺血性脑卒中患者日常生活活动（ADL）能力的相关性。 方法 选取90例缺血性脑卒中患者，收集一般资料并采用Barthel指数（BI）量表评估患者的ADL能力，提取粪便样本并采用气相色谱仪（GC）分析测定乙酸、丙酸、丁酸、异丁酸、戊酸、异戊酸水平，采用Spearman相关分析找到与BI总分存在相关性的SCFAs，通过线性回归分析探讨BI总分与SCFAs的相关性。 结果 患者粪便样本中，丙酸、丁酸水平与BI总分存在相关性（P＜0.05）。将丙酸水平、丁酸水平、年龄、性别、体重指数（BMI）、病程、高血压病史、糖尿病病史、其它SCFAs水平等数据分批纳入4个模型分析，从模型1至模型4，丙酸水平与BI总分的β值(95% CI)分别为0.73(0.20,1.25)、0.66(0.10,1.22)、0.54(0.07,1.21)、0.56(0.08,1.40)；丁酸水平与BI总分的β值(95% CI)分别为0.79(0.17,1.41)、0.75(0.06,1.41)、0.72(0.03,1.42)、1.00（0.06,1.94），提示粪便中丙酸、丁酸水平与BI总分呈正相关（P＜0.05）。 结论 缺血性脑卒中患者粪便中的丙酸和丁酸水平与BI总分呈正相关，测定丙酸和丁酸水平可能在评价ADL能力方面起到重要作用。 |
| 英文摘要: |
| Objective To seek a correlation between short-chain fatty acids (SCFAs) and skill in the activities of daily living (ADL) after an ischemic stroke. Methods Ninety ischemic stroke survivors were assessed using the Barthel Index (BI). Fecal samples were collected and analyzed for the concentration of acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid, and isovaleric acid using gas chromatography. Spearman correlation analysis was conducted to identify SCFAs that correlated with the total BI score. Linear regressions were evaluated to explore the correlation between the total BI score and SCFAs. Results The concentrations of propionic and butyric acids in the feces were found to correlate significantly with the total BI scores. Data including propionic acid and butyric acid levels, age, gender, body mass index, disease duration, any history of hypertension or diabetes, and other SCFAs were included in the regression models. Propionic and butyric acid levels were found to be potentially useful predictors of total BI scores. Conclusions The concentration of propionic and butyric acids in the feces after an ischemic stroke can predict the survivor′s total BI score. Those concentrations could therefore be useful for predicting ADL ability. |
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