李晓勇,刘静,万琼.高强度间歇运动对自发性高血压大鼠肾脏肾素-血管紧张素系统的影响[J].中华物理医学与康复杂志,2023,45(8):673-677
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| 高强度间歇运动对自发性高血压大鼠肾脏肾素-血管紧张素系统的影响 |
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| DOI：10.3760/cma.j.issn.0254-1424.2023.08.001 |
| 中文关键词: 高强度间歇运动 自发性高血压大鼠 肾脏 肾素-血管紧张素系统 血压 |
| 英文关键词: High-intensity interval training Hypertension Kidneys Renin-angiotensin system Blood pressure |
| 基金项目:河南省重点研发与推广专项（科技攻关）项目（212102310266） |
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| 中文摘要: |
| 目的 观察高强度间歇运动对自发性高血压大鼠（SHR）血压水平及肾功能的影响，并探讨肾脏肾素-血管紧张素系统（RAS）在其间的作用机制。 方法 采用随机数字表法将20只雄性SHR大鼠分为高血压安静组及高血压运动组，同时选取10只Wistar-Kyoto大鼠纳入正常血压组。正常血压组及高血压安静组大鼠均置于鼠笼内安静饲养，高血压运动组大鼠则给予8周高强度间歇运动干预。于末次运动结束后检测各组大鼠血压水平、肾功能、肾脏一氧化氮（NO）和白细胞介素-6（IL-6）含量以及肾脏血管紧张素转换酶（ACE）、ACE2、血管紧张素1型受体（AT1R）、AT2R和Mas受体（MasR）蛋白表达量。 结果 与正常血压组比较，高血压安静组大鼠血压升高（P<0.05），肾功能减退（P<0.05），肾脏NO含量减少（P<0.05），IL-6含量升高（P<0.05），ACE和AT1R蛋白表达以及AT1R/AT2R比值升高（P<0.05），ACE2、AT2R及MasR蛋白表达下降（P<0.05）；与高血压安静组比较，高血压运动组大鼠血压明显下降（P<0.05），肾功能改善（P<0.05），肾脏NO含量升高（P<0.05），IL-6含量降低（P<0.05），ACE和AT1R蛋白表达以及AT1R/AT2R比值下降（P<0.05），ACE2、AT2R及MasR蛋白表达显著上调（P<0.05）。 结论 8周高强度间歇运动干预能通过调控肾脏RAS轴对SHR大鼠肾脏发挥保护作用。 |
| 英文摘要: |
| Objective To observe any effect of high-intensity interval training on the blood pressure and renal function of Wistar-Kyoto rats modeling spontaneous hypertension (SHR) and to explore the mechanism of the renal renin-angiotensin system′s (RAS′s) role in this process. Methods Twenty male SHR were randomly divided into a sedentary group and an exercise group, each of 10. Another 10 Wistar-Kyoto rats formed a normotensive control group. The rats in the normotensive and hypertensive sedentary groups were fed quietly in their cage, while the hypertensive exercise group performed high-intensity interval training for 8 weeks. After the last exercise, blood pressure, renal function, the kidney levels of nitric oxide and interleukin-6 (IL-6) and the protein expressions of angiotensin converting enzyme (ACE), ACE2, angiotensin type 1 receptor (AT1R), AT2R and Mas receptor (MasR) were measured. Results Compared with the normotensive group, the hypertensive sedentary group showed a significant increase in average blood pressure, IL-6, ACE and AT1R protein and the ratio of AT1R to AT2R. There was a significant decrease in the renal function, the average NO level and the expression of ACE2, AT2R and MasR protein. That group also showed a significant decrease in blood pressure, IL-6, ACE and AT1R protein expression and the AT1R:AT2R ratio compared with the hypertensive sedentary group, but a significant increase in renal function, average NO content and the expression of ACE2, AT2R and MasR protein. Conclusion Eight weeks of high-intensity interval training has a protective effect on the kidneys by regulating the renin-angiotensin system, at least in rats. |
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