朱明跃,吴岩峰,李怡阁,等.血清ω3多不饱和脂肪酸水平与脑卒中后认知障碍相关性的回顾性研究[J].中华物理医学与康复杂志,2023,45(2):141-145
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| 血清ω3多不饱和脂肪酸水平与脑卒中后认知障碍相关性的回顾性研究 |
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| DOI：10.3760/cma.j.issn.0254-1424.2023.02.011 |
| 中文关键词: ω3多不饱和脂肪酸 脑卒中后认知障碍 简明精神状态量表 相关性 |
| 英文关键词: Omega-3 polyunsaturated fatty acids Stroke Cognitive impairment Minimum Mental State Examination Correlation studies |
| 基金项目:江苏省卫生健康委医学科研面上项目(M2021064) |
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| 中文摘要: |
| 目的 回顾性分析血清ω3多不饱和脂肪酸(ω3-PUFAs)与脑卒中后认知障碍（PSCI）的相关性，探讨ω3-PUFAs在辅助诊断与评价PSCI中的应用价值。 方法 选取2019年1月～2022年3月在南京医科大学第二附属医院康复科、神经内科住院治疗的首次脑卒中患者77例，收集其临床资料，采用简明精神状态量表（MMSE）评分标准将患者分为PSCI组（43例）和非PSCI组（34例），通过病例资料、相关血清ω3-PUFAs检验报告，统计分析两组患者血清ω3-PUFAs水平的差异，检验血清ω3-PUFAs主要组成成分α亚麻酸（ALA)、二十碳五烯酸(EPA)、二十二碳六烯酸(DHA)、总值与MMSE评分之间的相关性，探讨PSCI发生的危险因素。 结果 PSCI组患者的ALA［5.00(3.42,7.56)μmol/L］、EPA［0.50(0.40,0.75)μmol/L］、DHA［2.86(2.11,3.30)μmol/L］、总值［8.93(6.47,10.83)μmol/L］均明显低于非PSCI组，差异有统计学意义（P<0.05）；Spearman相关性分析显示血清DHA水平与脑卒中患者的MMSE评分呈弱正相关性（rs=0.320，P<0.05）；Logistic回归分析显示血清DHA水平较低是发生PSCI的危险因素（P<0.05，OR=0.554，95%CI为0.368~0.835）。 结论 PSCI患者的血清ω3-PUFAs水平低于脑卒中后非认知障碍患者，血清DHA水平与MMSE评分呈弱正相关性，较低的血清DHA水平是发生PSCI的独立风险因素，ω3-PUFAs在辅助诊断与评价PSCI方面有较高的应用价值。 |
| 英文摘要: |
| Objective To quantify any correlation between serum levels of omega-3 polyunsaturated fatty acids (ω3-PUFAs) and post-stroke cognitive impairment (PSCI). Methods The clinical data of 77 patients hospitalized after a first stroke were analyzed. The Minimum Mental State Examination (MMSE) was used to divide them into impaired (PSCI) and unimpaired (non-PSCI) cohorts. The serum levels of ω3-PUFAs, α-linolenic acid (ALA), eieosapentaenoic acid (EPA) and dueosahexenoie acid (DHA) were compared between the two groups and correlated with the individuals′ MMSE scores. Results The average ALA, EPA, DHA and total ω3-PUFAs levels of PSCI group were in most cases significantly lower than those of the non-PSCI group. Spearman correlation analysis showed that serum DHA level was a weak positive predictor of the MMSE scores (R=0.32, P≤0.05). Logistic regression analysis indicated that low serum DHA level was an independent risk factor for PSCI (P≤0.01). Conclusions Cognitively impaired stroke survivors tend to have lower serum ω3-PUFAs levels than those without cognitive impairment. There is a weak positive correlation between serum DHA levels and MMSE scores. Low serum DHA level is an independent risk factor for PSCI. The serum level of ω3-PUFAs is of high value in the auxiliary diagnosis and evaluation of PSCI. |
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