文章摘要
程清,秦义婷,唐文庆,等.高频重复经颅磁刺激联合吸烟相关线索诱发对香烟成瘾的影响[J].中华物理医学与康复杂志,2021,43(5):443-447
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高频重复经颅磁刺激联合吸烟相关线索诱发对香烟成瘾的影响
  
DOI:10.3760/cma.j.issn.0254-1424.2021.05.015
中文关键词: 高频重复经颅磁刺激  吸烟相关线索  香烟成瘾
英文关键词: Transcranial magnetic stimulation  Smoking-related cues  Nicotine addiction
基金项目:国家重点研发计划(2018YFC1313600)
作者单位
程清 南京市栖霞区医院康复科南京 210046
南京医科大学第一附属医院康复医学中心南京 210029 
秦义婷 南京市栖霞区医院康复科南京 210046
南京医科大学第一附属医院康复医学中心南京 210029 
唐文庆 南京市栖霞区医院康复科南京 210046
南京医科大学第一附属医院康复医学中心南京 210029 
杨剑 南京市栖霞区医院康复科南京 210046
南京医科大学第一附属医院康复医学中心南京 210029 
秦雷 南京市栖霞区医院康复科南京 210046
南京医科大学第一附属医院康复医学中心南京 210029 
殷稚飞 南京医科大学第一附属医院康复医学中心南京 210029 
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中文摘要:
      目的 探讨作用于左侧背外侧前额叶皮质区(DLPFC)的高频重复经颅磁刺激(H-F rTMS)联合吸烟相关线索诱发对香烟成瘾患者香烟渴求度(VAS评分)、呼出气CO浓度(COppm)和睡眠质量(PSQI评分)的影响。 方法 60例香烟成瘾患者随机分为A组(相关线索诱发rTMS组)、B组(非相关线索诱发rTMS组)和C组(rTMS组),每组患者20例,在治疗过程中A、B组各有1例患者脱落。A组患者在H-F rTMS治疗的同时观看吸烟相关图片10 min,B组患者在H-F rTMS治疗的同时观看非吸烟相关图片10 min,C组患者仅给予H-F rTMS治疗。以上治疗均为每日1次,每周治疗5 d,连续治疗2周。3组患者均于治疗前和治疗2周后(治疗后)进行VAS评分、COppm和PSQI检测。 结果 治疗后,3组的香烟渴求度VAS评分、呼出CO浓度和PSQI评分较组内治疗前均显著下降,差异均有统计学意义(P<0.05)。A组治疗后的香烟渴求度VAS评分和呼出CO浓度分别为(24.74±15.77)分和(4.84±2.17)ppm,与B组和C组比较,差异均有统计学意义(P<0.05)。 结论 rTMS可显著改善香烟成瘾患者的香烟渴求、呼出气CO浓度和睡眠质量,其中H-F rTMS联合吸烟相关线索诱发的治疗效果最佳。
英文摘要:
      Objective To explore the effect of repetitive high-frequency magnetic stimulation (H-F rTMS) of the dorsolateral part of the prefrontal cortex (DLPFC) combined with smoking-related cues on nicotine addicts′ cigarette craving, the concentration of exhaled CO and sleep quality. Methods Sixty nicotine addicts were randomly divided into groups A, B and C, each of 20. All were given H-F rTMS five times a week for two weeks, while those in groups A and B watched smoking and non-smoking pictures for ten minutes, respectively. Before and after the intervention, all of the subjects self-reported their cigarette cravings using a visual analogue scale. Exhaled CO (COppm) was measured and the Pittsburgh sleep quality index (PSQI) was evaluated. Results After the intervention the average craving score, COppm and PSQI score had improved significantly in all three groups. The average craving score and COppm of group A were both significantly better than in the other two groups. Conclusions rTMS can significantly improve cigarette craving, COppm and sleep quality of cigarette adicts. Viewing smoking-related pictures as an addition to rTMS can even better the effects of rTMS.
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