张秀娟,鲁银山,张松,等.不同频率的高频重复经颅磁刺激对大鼠神经病理性疼痛的影响[J].中华物理医学与康复杂志,2021,43(3):200-205
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| 不同频率的高频重复经颅磁刺激对大鼠神经病理性疼痛的影响 |
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| DOI：10.3760/cma.j.issn.0254-1424.2021.03.002 |
| 中文关键词: 神经病理性疼痛 重复经颅磁刺激 高频率 |
| 英文关键词: Neuropathic pain Pain Transcranial magnetic stimulation High frequency irradiation |
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| 中文摘要: |
| 目的 观察高频重复经颅磁刺激(rTMS)对神经病理性疼痛模型大鼠的影响，并比较3种不同频率的rTMS对神经病理性疼痛的治疗效果，探索最佳治疗频率。 方法 选取健康成年雄性SD大鼠100只，随机分为假手术组、模型组、rTMS组、假刺激组，rTMS组又分为5 Hz组、10 Hz组、20 Hz组。于造模成功后第3天开始进行为期5 d或10 d的rTMS治疗。分别于术前、术后不同时间点对各组大鼠进行疼痛行为学评分，包括热痛敏缩足潜伏时（PWTL）、机械痛敏缩足阈值（PWMT）。 结果 治疗后各rTMS组的PWTL和PWMT值均较模型组不同程度增加，且10 Hz组、20 Hz组的PWTL、PWMT值增加较5 Hz组更明显，10 Hz和20 Hz组间的PWTL和PWMT值比较，差异无统计学意义（P＞0.05）。 结论 不同频率rTMS治疗神经病理性疼痛的疗效不同，10 Hz和20 Hz的疗效优于5 Hz。 |
| 英文摘要: |
| Objective To compare the effects of repetitive transcranial magnetic stimulation (TMS) at three different relatively high frequencies on neuropathic pain so as to find the best frequency. Methods One hundred Sprague-Dawley rats were randomly divided into a sham operation group, a model group, a TMS group and a control stimulation group. The TMS group was further divided into a 5Hz group, a 10Hz group, and a 20Hz group. The rats in the model, control stimulation and TMS groups received constriction injury of the sciatic nerve, while the rats in the sham group were given a sham version of the operation. On the third day after the operation the rats in the TMS group and the control stimulation group began to receive TMS treatment. Neuropatic pain was evaluated on the day before the operation, and on the 3rd, 5th, 7th, 10th and 12th days after the operation. The evaluations included the paw withdrawal thermal latency (PWTL) and the paw withdrawal mechanical threshold (PWMT). Results The average PWTLs and PWMTs in all of the TMS groups increased with the TMS treatment. Those of the 10Hz and 20Hz groups were significantly higher than the 5Hz group′s average, while there were no significant differences between the 10Hz group and 20Hz group. Conclusions High-frequency TMS at different frequencies has different effects on neuropathic pain, at least in rats. The treatment efficacy at 10 and 20Hz is superior to that at 5Hz. |
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