姚滔涛,陈卓铭,汪敏,等.孤独症患儿小脑磁共振波谱特征分析[J].中华物理医学与康复杂志,2020,42(6):546-549
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| 孤独症患儿小脑磁共振波谱特征分析 |
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| DOI：10.3760/cma.j.issn.0254-1424.2020.06.015 |
| 中文关键词: 孤独症 小脑 磁共振波谱 |
| 英文关键词: Autism Cerebellum Magnetic resonance spectroscopy |
| 基金项目:国家自然科学基金委员会资助项目（81372113）；教育部人文社会科学重点研究基地重大项目（1002879） |
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| 中文摘要: |
| 目的 通过磁共振波谱技术探讨孤独症患儿小脑代谢物特征，并分析其与临床症状的相关性。 方法 分别对14例孤独症患儿及8例对照组儿童双侧小脑白质感兴趣区进行波谱数据采集，对小脑的波谱谱线以及NAA、Cho、Cr的波峰进行观察, 并记录局部体素的NAA/Cr和Cho/Cr比值；分析孤独症患儿小脑部位代谢值与临床症状［儿童孤独症评定量表(CARS) 、孤独症行为量表(ABC)评分］及年龄的相关性。 结果 两组儿童双侧小脑白质代谢值未见明显统计学差异，但孤独症患儿右小脑Cho/Cr高于左小脑（P=0.044）；右小脑Cho/Cr与CARS评分呈正相关（r=0.548,P=0.042）；右小脑NAA/Cr与年龄呈正相关（r=0.613,P=0.020）。 结论 孤独症患儿左右小脑半球内存在代谢异常，小脑的代谢异常与孤独症患儿临床症状严重程度相关，且随着年龄的增长，其代谢存在逐步改善的趋势。 |
| 英文摘要: |
| Objective To explore the characteristics of cerebellar metabolites of autistic children using the magnetic resonance spectrum (MRS) and analyze their correlation with clinical symptoms. Methods An autism group (n=14) and a control group (n=8) both underwent bilateral MRS scans of their cerebella. The NAA, Cho and Cr absolute values were recorded along with the NAA/Cr and Cho/Cr ratios. Those values were correlated with clinical symptoms of autism (the CARS and ABC scales), as well as with age. Results There were no significant differences between the two groups in cerebellar metabolite levels, but the autism group exhibited significantly higher Cho/Cr ratios in the right cerebellum than in the left. There was a significant positive correlation between the Cho/Cr ratio in the right cerebellum and CARS scores, and between the NAA/Cr ratio in the right cerebellum and age. Conclusions There is metabolic abnormality in the left and right cerebellar hemispheres of autistic children. The metabolic abnormality is related to the severity of clinical symptoms. However, metabolism in the cerebellum improves gradually with age. |
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