吴少璞,李学,祁亚伟,等.经颅直流电刺激对伴快速眼动睡眠行为障碍-帕金森病患者睡眠障碍的影响[J].中华物理医学与康复杂志,2020,42(1):50-54
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| 经颅直流电刺激对伴快速眼动睡眠行为障碍-帕金森病患者睡眠障碍的影响 |
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| DOI：DOI:10.3760/cma.j.issn.0254-1424.2020.01.012 |
| 中文关键词: 经颅直流电刺激 快速眼动睡眠行为障碍 帕金森病 |
| 英文关键词: Transcranial direct current stimulation Parkinson′s disease Rapid eye movement sleep Sleep quality Depression |
| 基金项目:河南省科技厅科技攻关项目(162102310283) |
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| 中文摘要: |
| 目的 观察经颅直流电刺激(tDCS)对伴快速眼动睡眠行为障碍（RBD）帕金森病（PD）患者睡眠障碍的影响。 方法 选取2016年1月至2019年6月期间在我院治疗的54例PD-RBD患者作为研究对象，采用随机数字表法将其分为观察组（28例）及对照组（26例）。2组患者均给予常规抗PD药物治疗及护理，观察组患者在此基础上辅以tDCS治疗，对照组则辅以tDCS假刺激治疗。于治疗前、治疗4周后分别采用多导睡眠图（PSG）、汉密尔顿抑郁量表（HAMD）、PD睡眠量表(PDSS)、Epworth嗜睡量表(ESS)及PD生活质量问卷（PDQ-39）对2组患者进行疗效评定。 结果 治疗前2组患者总睡眠时间(TST)、睡眠潜伏期(SL)、睡眠效率(SE)、快速眼动睡眠时间(REMS)、醒觉指数(AI)、HAMD、ESS、PDSS及PDQ-39评分组间差异均无统计学意义（P>0.05）；治疗4周后观察组患者上述各项疗效指标均较治疗前明显改善（P<0.05）；对照组仅有TST、HAMD评分较治疗前明显改善（P<0.05）；通过进一步组间比较发现，治疗后观察组TST、SL、SE、REMS、AI、HAMD、ESS、PDSS及PDQ-39评分［分别为（359.57±28.12）min，（17.48±3.37）min，（75.49±18.25）%，（12.37±4.51）min，（24.17±8.94）次/小时，（6.3±2.3）分，（7.12±1.3）分，（118.08±24.06）分 和（22.55±8.19）分］均显著优于对照组水平，组间差异均具有统计学意义（P<0.05）。 结论 tDCS能明显改善PD-RBD患者睡眠质量及抑郁情绪，对提高患者生活质量具有重要意义。 |
| 英文摘要: |
| Objective To observe the influence of transcranial direct current stimulation (tDCS) on rapid eye movement sleep disorders among Parkinson′s disease (PD) patients. Methods Fifty-four PD patients were randomly divided into a treatment group (n=28) and a control group (n=26). Both groups were given routine drug treatment and nursing, while the treatment group was additionally provided with tDCS therapy. Both groups were evaluated using polysomnography (PSG), the Hamilton depression scale (HAMD), the pediatric daytime sleepiness scale (PDSS), the Epworth sleeping scale (ESS) and PD quality of life questionnaire-39 (PDQ-39) before and after four months of treatment. Results There were no significant differences between the two groups before the treatment. After the treatment, significant improvement was observed in the total sleep time (TST), sleep latency (SL), sleep efficiency (SE), rapid eye movement sleep (REMS), arousal index (AI), and in the HAMD, ESS, PDSS and PDQ-39 scores among the treatment group. In the control group only the average TST and HAMD score improved significantly. After the treatment, all of the treatment group′s average results were significantly better than the control group′s averages. Conclusion tDCS can significantly improve the sleep quality of patients with PD and relieve any depression, bettering their life quality. |
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