李琴英,王蓓,李亚楠,等.视神经脊髓炎谱系病患者痛性强直痉挛与脊髓损伤之间的关系探讨[J].中华物理医学与康复杂志,2020,42(4):344-347
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视神经脊髓炎谱系病患者痛性强直痉挛与脊髓损伤之间的关系探讨 |
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DOI:10.3760/cma.j.issn.0254-1424.2020.04.013 |
中文关键词: 视神经脊髓炎谱系病 痛性强直痉挛 美国脊髓损伤协会残损分级 |
英文关键词: Neuromyelitis optica Tonic spasm American Spinal Injury Association Impairment Scale |
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中文摘要: |
目的 探讨视神经脊髓炎谱系病(NMOSD)患者痛性强直痉挛(PTS)与脊髓损伤之间的关系。 方法 收集138例NMOSD患者的临床资料、血清抗水通道蛋白4抗体(AQP4-IgG)结果及磁共振检查结果,进行临床特点分析。同时对累及脊髓的NMOSD患者进行美国脊髓损伤委员会残损分级(AIS)评定,探讨PTS与脊髓损伤之间的关系。 结果 NMOSD患者中PTS的患病率为36.96%(51/138),51例伴发PTS的NMOSD患者均与脊髓病变相关,与不伴发PTS的NMOSD患者有非常显著的统计学差异(P<0.01)。伴发PTS的NMOSD患者起病年龄、性别、病程、AQP4-IgG阳性率、受累脊髓部位、节段范围以及AIS分级与不伴发PTS的NMOSD患者比较,差异无统计学意义(P>0.05)。 结论 PTS与脊髓病变相关,是缓解期及复发缓解期较为常见的症状。本研究未见PTS与受累脊髓部位及节段范围存在相关性,也未见PTS与AIS分级存在相关性。 |
英文摘要: |
Objective To investigate the relationship between painful tonic spasm (PTS) and spinal cord injury in patients with neuromyelitis optica spectrum disorder (NMOSD). Methods The clinical data, serum AQP4-IgG antibody levels and magnetic resonance data of 138 patients with NMOSD were analyzed. Those with spinal cord involvement were assessed using the American Spinal Injury Association Impairment Scale (AIS) to investigate the relationship between PTS and spinal cord injury. Results The prevalence of PTS among the NMOSD patients was 36% (51/138), and all of the 51 NMOSD patients with PTS showed spinal cord lesions, an incidence significantly different from those without PTS. However, there were no significant differences in the age of onset, gender, disease duration, AQP4-IgG levels, lesion location, range of spinal cord lesions, or AIS grade between the NMOSD patients with and without PTS. Conclusion PTS is a prevalent concomitant of NMOSD. As a common symptom of remission and recurrent remission, PTS is associated with myelopathy. This study failed to find any correlation between PTS and the affected spinal cord site or segment range. There was also no correlation between PTS and AIS grading among these subjects. |
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