郑凯.有氧运动对超重或肥胖儿童炎症因子、胰岛素抵抗及内皮功能的影响[J].中华物理医学与康复杂志,2020,42(3):193-197
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| 有氧运动对超重或肥胖儿童炎症因子、胰岛素抵抗及内皮功能的影响 |
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| DOI：DOI:10.3760/cma.j.issn.0254-1424.2020.03.001 |
| 中文关键词: 有氧运动 超重/肥胖 儿童 炎症因子 胰岛素抵抗 内皮细胞功能 |
| 英文关键词: Aerobic exercise Overweight Obesity Children Inflammatory factors Insulin resistance Endothelium function |
| 基金项目:河南省重大科技攻关项目(152102310117) |
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| 中文摘要: |
| 目的 观察24周有氧运动对超重/肥胖儿童炎症因子、胰岛素抵抗及内皮功能的影响。 方法 采用随机数字表法将80例超重/肥胖儿童分为对照组及运动组，对照组仅参加学校组织的体育课（2次/周，45 min/次），运动组在对照组基础上进行24周有氧运动干预（包括跑步、游泳、蹬车、游戏等）。于实验前、后分别测定2组受试者血压、心率、体重、体重指数（BMI）、身体成分、肱动脉血流介导的血管舒张反应（FMD）以及血清C-反应蛋白（CRP）、血脂、血糖和胰岛素含量，利用稳态模型评估法（HOMA）计算胰岛素抵抗指数（IRI）。采用t检验对所得数据进行统计学分析。 结果 实验前受试者血清CRP与IRI（r＝0.670，P＝0.002）呈正相关，在校正基线变量后，该关联仍具有统计学意义（r＝0.513，P＝0.031）。实验后与组内实验前比较，发现运动组FMD［实验前为（5.96±1.02）%，实验后为（7.45±2.54）%，t＝-3.743，P＝0.001］明显升高，对照组FMD变化无统计学意义［实验前为（6.10±1.03）%，实验后为（5.92±0.94）%，t＝0.809，P＝0.424］；两组受试者身体形态学（体重、BMI和身体成分）、血液动力学（血压和心率）及其他血清生化（血脂、血糖和胰岛素）参数的变化均无统计学意义（P>0.05）。 结论 超重/肥胖儿童的血清CRP与IRI具有独立正相关性，24周的有氧运动可改善超重/肥胖儿的血管内皮功能。 |
| 英文摘要: |
| Objective To investigate the effects of 24 weeks of aerobic exercise on inflammatory factors, insulin resistance and endothelial function among overweight or obese children. Methods Eighty overweight or obese children were randomly divided into a control group and an exercise group, each of 40. Both groups took part in physical activity organized by a school (twice/week, 45 min/time), while the exercise group performed an additional 24-week aerobic exercise program. Blood pressure, heart rate, body weight, body mass index (BMI), body composition, flow-mediated dilation (FMD) of the brachial artery, serum C-reactive protein (CRP), lipids, glucose and insulin were monitored. Insulin resistance indices (IRIs) were estimated from a homeostatic model assessment. Results A baseline positive correlation was found between serum CRP and IRI which remained significant after adjusting the baseline variables. After the intervention, the average FMD of the exercise group had increased significantly while no significant improvement was found in the control group. However, after the intervention, no significant differences were found between the two groups in terms of the other measurements. Conclusions The serum CRP of overweight/obese children is independently associated with IRI. Twenty-four weeks of aerobic exercise can improve vascular endothelial function. |
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