彭梅,曾宪容,潘福琼,等.高压氧联合湿性愈合治疗大鼠皮肤慢性难愈合溃疡的疗效研究[J].中华物理医学与康复杂志,2020,42(2):117-119
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| 高压氧联合湿性愈合治疗大鼠皮肤慢性难愈合溃疡的疗效研究 |
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| DOI：DOI:10.3760/cma.j.issn.0254-1424.2020.02.005 |
| 中文关键词: 高压氧 湿性愈合 难愈合溃疡 疗效 |
| 英文关键词: Hyperbaric oxygen Wet healing Skin ulcers |
| 基金项目:四川省人民医院苗圃课题(30305031044) |
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| 中文摘要: |
| 目的 观察高压氧联合湿性愈合治疗大鼠皮肤慢性难愈合溃疡的疗效。 方法 将60只雄性SD大鼠分为普通治疗组、湿性愈合组、联合治疗组，每组20只。大鼠常规饲养1周后造模，造模前6 h禁食，制成慢性皮肤溃疡模型。普通治疗组大鼠按一般性皮肤溃疡治疗，湿性愈合组大鼠按湿性愈合治疗，联合治疗组大鼠在湿性愈合治疗基础上，辅以6个疗程的高压氧治疗。治疗2个疗程、4个疗程、6个疗程时，计算各组大鼠的创面愈合率，采用组织病理学分析对大鼠皮肤创面的恢复情况进行评定。 结果 与普通治疗组同时间点比较，湿性愈合组和联合治疗组大鼠2个疗程、4个疗程、6个疗程的创面愈合率均较高（P<0.05）。与湿性愈合组同时间点比较，联合治疗组大鼠2个疗程［（51.0±8.7）%］、4个疗程［（75.0±5.6）%］、6个疗程［（88.0±4.4）%］的创面愈合率均较高（P<0.05）。与普通治疗组比较，湿性愈合组和联合治疗组大鼠组织病理学评分较优异（P<0.05）。与湿性愈合组比较，联合治疗组大鼠组织病理学评分较优异（P<0.05）。 结论 单一湿性愈合治疗慢性皮肤溃疡的疗效优于普通治疗，高压氧联合湿性愈合治疗慢性皮肤溃疡的疗效更为优异。 |
| 英文摘要: |
| Objective To explore the effect of combining hyperbaric oxygen inhalation with wet healing in the treatment of chronic refractory ulcers of the skin. Methods Sixty male Sprague-Dawley rats were randomly formed into a general treatment group (group A), a wet healing group (group B), and a hyperbaric oxygen + wet healing group (group C), each of 20. Chronic and refractory skin ulcers were induced on all of the rats after one week of routine feeding and 6 hours of fasting. Six courses （once daily for 10 days/course）of the three treatments were then administered. After 2, 4 and 6 courses of treatment the wound healing rate and recovery were analyzed using histopathological methods. Results After 2, 4 and 6 courses of treatment, the average wound healing rates of groups B and C were significantly higher than group A′s average, and that of group C was significantly better than that of group B. After 6 courses of treatment, group C′s average histopathology score was significantly higher than that of group B, and those of groups B and C were both significantly higher than group A′s average. Conclusion Single wet healing is better than common treatment for chronic skin ulcers, but hyperbaric oxygen inhalation can further improve its effectiveness. |
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