彭小岭,曾宪容,潘福琼,等.高压氧对重型颅脑损伤患者血流动力学和颅内压影响的Meta分析[J].中华物理医学与康复杂志,2019,41(11):862-870
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| 高压氧对重型颅脑损伤患者血流动力学和颅内压影响的Meta分析 |
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| DOI：DOI:10.3760/cma.j.issn.0254-1424.2019.11.016 |
| 中文关键词: 高压氧 重型颅脑损伤 颅内压 Meta分析 |
| 英文关键词: Hyperbaric oxygen Craniocerebral injury Brain trauma, intracranial pressure Meta-analysis |
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| 中文摘要: |
| 目的 评价高压氧（HBO）对重型颅脑损伤（STBI）患者血流动力学及颅内压（ICP）的影响。 方法 计算机检索PubMed、cochrane Library、Embase、Lancet、CBM、CNKI、VIP和wanFang Data等数据库中关于高压氧治疗重型颅脑损伤疗效的随机对照试验，检索时限从建库至2018年4月。由2名研究者按纳入和排除标准独立筛选文献、提取资料并评价纳入文献方法学质量后，采用RevMan 5.2版循证医学软件进行Meta分析。 结果 共纳入8个随机对照试验(RCTs)，共计725例患者。Meta分析结果显示，治疗第3天、第5天、第10天后，高压氧组的血流动力学指标、ICP、摄氧率、格拉斯哥昏迷量表评分（GCS）、有效率均显著优于对照组，差异均有统计学意义（P<0.01）；但治疗第1天后，高压氧组的血流动力学指标和ICP与对照组比较，差异均无统计学意义（P>0.01）。 结论 高压氧治疗重型颅脑损伤疗效好，值得临床推广。 |
| 英文摘要: |
| Objective To systematically evaluate the effects of hyperbaric oxygen on the hemodynamics and intracranial pressure of patients with severe craniocerebral injury (STBI). Methods Reports of randomized and controlled trials applying hyperbaric oxygen in the treatment of STBI were retrieved from the Pubmed, Cochrane Library, Embase, CBM, CNKI, VIP and Wan Fang databases. Each report found was evaluated by two researchers independently applying pre-defined inclusion and exclusion criteria. The data were extracted and combined and a meta-analysis was performed. Results Eight trials involving 725 patients were included in the meta-analysis. They combined to demonstrate that intracranial pressure, oxygen uptake and scores on the Glasgow coma scale improved significantly more in the hyperbaric oxygen group than in the control group after between 3 and 10 days of treatment. Conclusion Hyperbaric oxygen therapy is effective in treating severe craniocerebral injury and it is worthy of clinical application. |
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