杨旭,孙世龙,楚金亭,等.高压氧治疗非动脉炎性前部缺血性视神经病变的疗效观察[J].中华物理医学与康复杂志,2019,41(11):829-832
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| 高压氧治疗非动脉炎性前部缺血性视神经病变的疗效观察 |
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| DOI：DOI:10.3760/cma.j.issn.0254-1424.2019.11.006 |
| 中文关键词: 视神经病变，缺血性 高压氧 视野 平均敏感度 |
| 英文关键词: Optic neuropathy Ischemia Hyperbaric oxygen therapy Field of view Visual sensitivity |
| 基金项目:河南省科技攻关项目（162102310211） |
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| 中文摘要: |
| 目的 观察和探讨高压氧治疗非动脉炎性前部缺血性视神经病变（NAION）的临床疗效。 方法 采用随机数字表法将符合纳入标准的139例NAION患者分为对照组（72例）和高压氧组（67例）。对照组给予甲泼尼龙琥珀酸钠、甲钴胺、复方樟柳碱等常规治疗；高压氧组则给予常规治疗的同时行高压氧治疗，舱压0.2 MPa，加压时间20 min，稳压吸氧60 min，中间吸舱内空气10 min，减压20 min，共治疗110 min，每日1次，10次为1个疗程，共治疗30 d。分别于治疗前和治疗30 d后（治疗后），观察并分析2组患者的视力、视野平均敏感度(MS)，并根据视力、视野MS等改变情况，评定治疗有效率。 结果 治疗前，2组患者的视力［对照组（4.37±0.30），高压氧组（4.31±0.38）］及视野MS［对照组（12.84±1.08），高压氧组（13.17±1.18）］组间比较，差异均无统计学意义（P>0.05）。治疗后，高压氧组患者的视力 ［（4.88±0.25）］和视野MS［（16.68±1.19）］明显高于组内治疗前（P<0.05），亦明显高于对照组治疗后［视力（4.59±0.25），视野MS（13.94±1.19）］，差异均有统计学意义（P<0.05）。治疗后，高压氧组患者的总有效率（91.04%）明显高于对照组（75.00%），组间差异有统计学意义（P<0.05）。 结论 常规治疗联合高压氧治疗可以明显提高NAION患者的视力、视野MS及其临床疗效。 |
| 英文摘要: |
| Objective To observe and explore the therapeutic efficacy of hyperbaric oxygen (HBO) in the treatment of non-arteritic anterior ischemic optic neuropathy (NAION). Methods A total of 139 NAION patients were randomly divided into a control group of 72 and a hyperbaric oxygen group of 67. Both groups were given conventional drugs including prednisolone, mecobalamin and compound anisodine, while the hyperbaric oxygen group was additionally provided with hyperbaric oxygen treatment at a pressure of 0.2MPa once a day for 30 days. Each day′s treatment lasted for 110 minutes, including 20 minutes at increasing pressure, 20 minutes decreasing and 60 minutes with the pressure stable at 0.2MPa. Before and after the 30-day treatment, the visual acuity and visual mean sensitivity (MS) of the two groups were observed and compared. Results There was no significant difference between the control group and the hyperbaric oxygen group in terms of average visual acuity or visual MS before the treatment. Afterward the average visual acuity (4.88±0.25) and visual MS (16.68±1.19) of the hyperbaric oxygen group were significantly higher than before the treatment and significantly better than those of the control group. The total effective rate of the hyperbaric oxygen group was 91%, significantly higher than that of the control group (75%). Conclusions Conventional treatment combined with hyperbaric oxygen therapy can significantly promote the visual acuity and visual MS of NAION patients. |
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