王威，江伟锋，项洁.经颅直流电刺激治疗抑郁症疗效的Meta分析[J].中华物理医学与康复杂志,2018,40(9):689-694
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| 经颅直流电刺激治疗抑郁症疗效的Meta分析 |
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| DOI： |
| 中文关键词: 经颅直流电刺激 抑郁症 Meta分析 |
| 英文关键词: Transcranial direct current stimulation Depression Meta-analysis |
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| 中文摘要: |
| 目的 系统评价经颅直流电刺激治疗抑郁症的疗效。 方法 利用计算机检索Pubmed、Embase、Cochrane library、万方数据库、维普数据库、中国知网数据库中关于经颅直流电刺激治疗抑郁症临床疗效的随机对照试验，检索时限为建库至2018年1月。由2名研究者按纳入标准和排除标准筛选文献、提取数据、质量评价，采用RevMan5.3版软件对最终纳入的文献数据进行统计学分析。 结果 最终纳入11篇随机对照试验，共565例研究对象。Meta分析结果显示：经颅直流电刺激可以有效改善抑郁症患者的抑郁症状。主要结果：抑郁症量表评分［标准化均数差（SMD）=-0.67,95%CI（-0.84，-0.49）,P<0.05］。次要结果：有效率［比值比（OR）=2.87,95%CI（1.96,4.20）,P<0.05］，缓解率［OR=1.85,95%CI（1.16,2.96）,P<0.05］。 结论 经颅直流电刺激对抑郁症患者有显著疗效，但是由于受纳入文献质量和样本量的限制，上述结论仍需要开展更大样本、更高质量的随机对照试验进行验证。 |
| 英文摘要: |
| Objective To evaluate the effectiveness of transcranial direct current stimulation (tDCS) in the treatment of depression. Methods The randomized and controlled trials (RCTs) of tDCS in treating depression were searched in electronic databases including Pubmed, Embase, Cochrane library, Wanfang, VIP, CNKI databases all the data until January 2018. All of the studies were evaluated by 2 researchers according to inclusion criteria and exclusion criteria and the data were extracted and assessed by using the RevMan5.3 software. Results Totally 11 RCTs studies (n=565 patients) were included in the meta-analysis. The results demonstrated that tDCS was beneficial on depression, with the depression score: ［SMD=-0.67, 95%CI (-0.84, -0.49), P<0.05］, response rate; ［OR=2.87, 95%CI (1.96, 4.20), P<0.05］ and remission rate: ［OR=1.85, 95%CI (1.16, 2.96), P<0.05］. Conclusion tDCS is of significant effect in treating depression. However, the RCTs included are of a relatively small number of subjects and limited quality, further studies should be focused on the randomized controlled trials of larger sample and higher quality. |
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