乔娜，燕铁斌，卢健军，郭永亮，郑文华.经颅直流电刺激对帕金森病早期患者步行功能的影响[J].中华物理医学与康复杂志,2018,40(7):509-512
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| 经颅直流电刺激对帕金森病早期患者步行功能的影响 |
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| DOI： |
| 中文关键词: 经颅直流电刺激 帕金森病 步行 步态分析 |
| 英文关键词: Transcranial direct current stimulation Parkinson′s disease Walking Gait analysis |
| 基金项目:国家自然科学基金项目（81772447）；广州市科技局产学研协同创新重大专项（201704020140） |
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| 中文摘要: |
| 目的 探讨经颅直流电刺激（tDCS）对帕金森病（PD）早期患者步行功能的影响。 方法 将30例PD早期患者按照随机数字法分为干预组和对照组，每组15例。在常规治疗的基础上，两组均接受tDCS治疗，干预组治疗电流为2mA，对照组为安慰电流；两组治疗时间均为每次20min，每日1次，连续治疗5d。治疗前和治疗5d后（治疗后），分别对患者进行评估，采用计时起立-行走测试评估患者的步行功能，用三维步态分析采集患者行走时的步速、步频和步宽等时空参数。 结果 治疗前、后，2组患者TUGT比较，差异均无统计学意义（P>0.05）。治疗后，干预组TUGT［（9.67±2.27）s］较组内治疗前［（10.85±2.37）s］降低，差异有统计学意义（P<0.05）。治疗前，2组患者步速、步频和步宽比较，差异无统计学意义（P>0.05）。治疗后，仅干预组治疗后步频［（111.00±7.66）step/s］较组内治疗前［（108.60±10.24）step/s］增加，差异有统计学意义（P<0.05）。与对照组治疗后比较，干预组步宽［（0.088±0.02）m］较大，差异有统计学意义（P<0.05）。 结论 tDCS可改善PD早期患者的步行功能，提高行走的稳定性。 |
| 英文摘要: |
| Objective To explore the effect of transcranial direct current stimulation (tDCS) on the walking function of patients with early Parkinson′s disease. Methods Thirty patients with early Parkinson′s disease were randomly divided into an intervention group (n=15) and a control group (n=15). In addition to routine treatment, both groups were apparently provided with tDCS, though the current intensity for the intervention group was 2mA and that of the control group was zero. Both groups were treated for 20min every day for 5 days in succession. Before and after the treatment, all of the patients were evaluated using the timed up and go test (TUGT) and their gaits were analyzed to determine step velocity, cadence and width. Results Before and after the treatment there were no significant differences between the two groups in terms of average TUGT time, though the average TUGT time had decreased significantly compared with before the treatment. Before the treatment there were no significant differences between the two groups in average step velocity, cadence or width. After the treatment, significant improvements were observed only in the intervention group. The average step width of the intervention group was then significantly bigger than that of the control group. Conclusion Transcranial direct current stimulation can improve the walking function and stability of early Parkinson′s patients. |
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