彭小岭，曾宪容，潘福琼，谢清明，彭梅.不同介入时间和不同疗程高压氧治疗对脑出血大鼠神经功能的影响[J].中华物理医学与康复杂志,2018,40(5):321-324
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| 不同介入时间和不同疗程高压氧治疗对脑出血大鼠神经功能的影响 |
| Hyperbaric oxygen therapy can help restore neurological function after intracerebral hemorrhage |
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| DOI： |
| 中文关键词: 高压氧治疗 介入时间 疗程 脑出血 神经功能恢复 |
| 英文关键词: Hyperbaric oxygen treatment Intervention scheduling Cerebral hemorrhage Neurological function recovery |
| 基金项目:四川省人民医院苗圃课题（30305031041） |
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| 中文摘要: |
| 目的 观察不同介入时间和不同疗程的高压氧（HBO）治疗对脑出血（ICH）大鼠神经功能的影响。 方法 将SD大鼠60只采用自体股动脉血法制作大鼠脑出血模型，造模成功后按随机数字表法随机分为不进行HBO治疗的无HBO组和进行HBO治疗的HBO组。HBO组按脑出血造模成功后HBO介入的不同时间分为5个亚组，包括造模成功后3 h开始HBO治疗的HBO 3 h组；造模成功后6 h开始HBO治疗的HBO 6 h组，造模成功后1 d开始HBO治疗的HBO 1 d组，造模成功后2 d开始HBO治疗的HBO 2 d组，造模成功后7 d开始HBO治疗的HBO 7 d组，每个亚组6只大鼠；无HBO组也按照HBO组的分组方法分为5个亚组（均不接受HBO治疗），包括无HBO 3 h组、无HBO 6 h组、无HBO 1 d组、无HBO 2 d组和无HBO 7 d组，每个亚组6只大鼠。分别于治疗前、治疗10 d后、治疗20 d后、治疗30 d后共4个时间点采用Longa评分法对2组（10个亚组）大鼠进行神经功能缺损评分。 结果 HBO治疗10 d、20 d、30 d后，HBO组各亚组与无HBO组同介入时间亚组比较，差异均有统计学意义（P<0.05）。治疗10 d后、治疗20 d后，HBO 3 h组分别为（2.17±0.75）分和（1.00±0.63）分，分别与HBO 2 d组大鼠神经功能评分比较，差异均有统计学意义（P<0.05）。治疗10 d后、治疗20 d后、治疗30 d后，HBO 3 h组与HBO 7 d组大鼠神经功能评分比较，差异均有统计学意义（P<0.05）。治疗10 d、治疗20 d后，HBO 6 h组与HBO 2 d组大鼠神经功能评分比较，差异均有统计学意义（P<0.05），治疗10 d后、治疗20 d后、治疗30 d后，HBO 6 h组与HBO 7 d组大鼠神经功能评分比较，差异均有统计学意义（P<0.05）。治疗10 d后、治疗20 d后，HBO 1 d组与HBO 2 d组大鼠神经功能评分比较，差异均有统计学意义（P<0.05）；治疗10 d后、治疗20 d后、治疗30 d后，HBO 1 d组与HBO 7 d组大鼠神经功能评分比较，差异均有统计学意义（P<0.05）。治疗10 d后、治疗20 d后、治疗30 d后，HBO 2 d组与HBO 7 d组大鼠神经功能评分比较，差异均有统计学意义（P<0.05）。HBO 3 h组、HBO 6 h组、HBO 1 d组、HBO 2 d组4个亚组的大鼠HBO治疗10 d后与组内HBO治疗20 d后大鼠神经功能评分比较,差异均有统计学意义（P<0.05）；治疗30 d后，HBO组各亚组与组内治疗10 d和20 d后比较，差异均有统计学意义（P<0.05）。 结论 HBO治疗可降低脑出血大鼠神经功能评分，促进神经功能的恢复，HBO介入时间以脑出血后≤1 d为最佳，且疗程越长则疗效越好。 |
| 英文摘要: |
| Objective To observe the effect of hyperbaric oxygen (HBO) therapy on neurological functioning in rats modelling cerebral hemorrhage (ICH). Methods Sixty Sprague-Dawley rats had intracerebral hemorrhage induced by injecting autologous blood. They were then randomly divided into an HBO-free group and an HBO group, each of 30 according to a random number table. The HBO group was further divided into HBO 3 h, HBO 6 h, HBO 1 d, HBO 2 d and HBO 7 d groups which received HBO therapy for 3 hours, 6 hours, 1 day, 2 days and 7 days respectively. Each had 6 members. The HBO-free rats were also divided into analogous HBO-free 3 h, HBO-free 6 h, HBO-free 1 d, HBO-free 2 d and HBO-free 7 d groups,and give no HBO intervention. All of the rats were evaluated for neurological impairment using the Longa scoring method before the treatment and 10 days, 20 days and 30 days afterward. Results After 10, 20 and 30 days of HBO treatment, there were significant differences in neurological functioning between each pair of HBO-free and HBO-treated groups. After 10 and 20 days of HBO treatment the average neurological function score of the HBO 3 h group was significantly different from that of the HBO 2 d group. The average score in the HBO 7 d group was also significantly different from that of the HBO 3 h, HBO 6 h, HBO 1 d and HBO 2 d groups after 10, 20 and 30 days of HBO treatment. The average scores of the HBO 3 h, HBO 6 h, HBO 1 d and HBO 2 d groups improved significantly between 10 and 20 days after the treatment. The average score of the rats which received 30 days of treatment was also significantly different from those after 10 and 20 days. Conclusion HBO treatment can improve neurological function after cerebral hemorrhage, at least in rats. The best time to start HBO treatment is no later than 24 hours after the hemorrhage. The curative effect increases with extension of the treatment′s duration. |
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