喻澜，崔高亮，徐群，郭铁成.脉冲电磁场对脑卒中后男性骨质疏松患者骨密度和骨代谢的影响[J].中华物理医学与康复杂志,2018,40(11):830-833
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| 脉冲电磁场对脑卒中后男性骨质疏松患者骨密度和骨代谢的影响 |
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| DOI： |
| 中文关键词: 脉冲电磁场 骨代谢 骨密度 |
| 英文关键词: Electromagnetic fields Pulsed electromagnetic fields Bone metabolism Bone mineral density |
| 基金项目:湖北省自然科学基金(2016CFB676) |
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| 摘要点击次数: 4259 |
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| 中文摘要: |
| 目的 探讨脉冲电磁场(PEMFS)对脑卒中后男性骨质疏松患者骨密度和骨代谢的影响。 方法 选取符合骨质疏松诊断标准的脑卒中后男性患者50例，随机分为对照组和治疗组，每组患者25例。2组患者均给予常规康复和口服碳酸钙D3片治疗，治疗组在此基础上增加PEMFS治疗。于治疗前和治疗12周后（治疗后）检测2组患者的骨密度、骨特异性碱性磷酸酶（B-ALP）、I型前胶原氨基端前肽（PINP）和β-Ⅰ型胶原交联羧基末端肽（β-CTx）。 结果 治疗后，2组患者腰椎、股骨颈、大转子以及Ward′s三角区的骨密度值均较组内治疗前增高(P<0.05)，治疗组患者治疗后的腰椎和股骨颈的骨密度值分别为（0.802±0.107）g/cm2和（0.670±0.112）g/cm2，均高于对照组治疗后，差异均有统计学意义(P<0.05)。治疗后，2组患者的B-ALP、PINP、β-CTx与组内治疗前比较，差异均有统计学意义(P<0.05)，且治疗组患者治疗后的B-ALP、PINP、β-CTx与对照组治疗后比较，差异均有统计学意义(P<0.05)。 结论 在常规康复治疗和口服碳酸钙D3片的基础上增加PEMFS治疗可促进脑卒中后男性骨质疏松患者的骨形成，减少其骨吸收，提高其骨密度。 |
| 英文摘要: |
| Objective To investigate the effect of a pulsed electromagnetic field (PEMFS) on bone mineral density and bone metabolism in males with osteoporosis after a stroke. Methods Fifty male stroke survivors with osteoporosis were randomly divided into a control group and a treatment group, both of 25. Both groups were treated with routine rehabilitation, oral calcium carbonate and vitamin D3 tablets, while the treatment group was additionally provided with PEMFS treatment. The subjects′ bone mineral density (BMD) and their blood levels of bone-specific alkaline phosphatase (B-ALP), type I procollagen amino-terminal peptide (PINP) and type β-I collagen cross-linked carboxy-terminal peptide (β-CTx) were measured before and after the 12 weeks of treatment. Results After the treatment the BMD values of the lumbar spine, femoral neck, trochanter and Ward′s triangle had increased significantly in both groups, but the average BMD values of the lumbar spine and femoral neck in the treatment group were significantly higher than those of the control group. After the treatment, the average B-ALP, PINP and β-CTx levels of both groups had also improved significantly compared with before the treatment, but the average improvement in all three among the treatment group was significantly greater than among the controls. Conclusion PEMFS treatment supplementing routine rehabilitation, oral calcium carbonate and vitamin D3 tablets can improve bone formation, reduce bone resorption and increase bone mineral density in men after a stroke. |
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