王杰,杨诚,卫小梅,等.前额叶在老年人吞咽中作用的任务态功能磁共振研究[J].中华物理医学与康复杂志,2020,42(12):1091-1096
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| 前额叶在老年人吞咽中作用的任务态功能磁共振研究 |
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| DOI：10.3760/cma.j.issn.0254-1424.2020.12.010 |
| 中文关键词: 功能磁共振 吞咽 认知 前额叶 |
| 英文关键词: Functional MRI Swallowing Cognition Prefrontal lobes |
| 基金项目:国家自然科学基金委员会资助项目(81672256) |
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| 中文摘要: |
| 目的 通过任务态功能性磁共振（fMRI）技术观察老年人的吞咽活动和认知网络，分析两者关系。 方法 选取13名健康老年人，年龄61～82岁，蒙特利尔认知评估量表（MoCA）评分≥26分，吞咽造影检查（VFSS）显示吞咽时无渗漏、误吸，行吞咽和认知任务态fMRI，分析两任务的激活脑区。 结果 吞咽和认知任务存在共同的激活脑区，即双侧小脑、枕叶、中央前回、中央后回、额中回、下顶叶等。吞咽任务中右侧前额叶正激活，左侧前额叶大部分为负激活，而认知任务中双侧前额叶均为正激活，且吞咽任务感觉区的激活范围大于运动区。 结论 老年人吞咽活动中右侧前额叶更具优势，右侧前额叶为吞咽和认知活动共同的神经节点。 |
| 英文摘要: |
| Objective To observe the swallowing and cognitive networks of elderly persons using the task-related functional magnetic resonance imaging (fMRI), and to analyze their relationship. Methods Thirteen healthy participants (5 males and 8 females) aged 61 to 82 with a score of at least 26 on the Montreal cognitive assessment and no penetration or aspiration evident in a videofluoroscopic study of swallowing were given swallowing- and cognition-related tasks while fMRI was performed. Results The two tasks activated some common areas such as the bilateral cerebellum, the occipital lobe, the precentral gyrus, the postcentral gyrus, the middle frontal gyrus and the inferior parietal lobe. In the swallowing task, the right prefrontal lobe was positively activated but most of the left lobe was negative stimulated. However, in a Stroop color and word test the bilateral prefrontal lobes were positively activated, and more of the postcentral area was stimulated than of the precentral. Conclusions The right prefrontal lobe may be the dominant area for swallowing. It may also be the common area important for both swallowing and cognition. |
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