李三松,刘瑞敏,王军,等.超声引导下不同剂量A型肉毒毒素注射治疗儿童流涎症的临床研究[J].中华物理医学与康复杂志,2020,42(11):995-998
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| 超声引导下不同剂量A型肉毒毒素注射治疗儿童流涎症的临床研究 |
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| DOI：10.3760/cma.j.issn.0254-1424.2020.11.008 |
| 中文关键词: 剂量 肉毒毒素 流涎症 |
| 英文关键词: Dosage Botulinum toxin Sialorrhoea |
| 基金项目:河南省医学科技攻关计划项目（201702101）；河南省医学科技攻关计划项目（SBGJ2018047） |
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| 中文摘要: |
| 目的 观察超声引导下不同剂量A型肉毒毒素（BoNT-A）治疗儿童流涎症的临床疗效及不良反应。 方法 纳入40例流涎症患儿，按照随机数字表法分为A、B两组，每组20例。BoNT-A注射在彩色多普勒超声仪引导下进行，在超声引导下将BoNT-A注射至每个患儿的双侧腮腺及下颌下腺，每侧腮腺各取2个点，共4个点，每个点均注射10 U；每侧下颌下腺取1个点，A组每点注射10 U，B组每点注射20 U。治疗前及治疗后2周、8周、12周，采用教师分级法（TDS）、流涎商数和Saxon测试分别对2组患儿的流涎情况进行评估，并观察注射后患儿的不良反应。 结果 2组患儿治疗前TDS分级评分、1 min流涎量、流涎商数评分比较，差异无统计学意义（P＞0.05）。与组内治疗前比较，2组患儿治疗后各时间点的TDS分级评分、1 min流涎量、流涎商数评分均降低（P＜0.05）。2组患儿治疗后同时间点TDS分级评分、1 min流涎量、流涎商数评分比较，差异无统计学意义（P＞0.05）。 结论 10 U、20 U BoNT-A注射均可改善儿童流涎症的临床症状，超声引导下注射精确、安全，未观察到注射后严重不良反应。 |
| 英文摘要: |
| Objective To observe the clinical efficacy and any side effects of using ultrasound-guided injection of botulinum toxin A in treating juvenile sialorrhoea. Methods Forty children with sialorrhoea were randomly divided into group A and group B, each of 20. Under the guidance of color Doppler ultrasound, botulinum toxin type A (BoNT-A) was injected into the children′s 2 parotid glands and their submandibular glands. Each parotid gland was injected with 20u of BoNT-A, while 10u was injected into the submandibular gland in group A and 20u was injected in group B. Before and 2, 8 and 12 weeks after the injections, the children′s sialorrhoea was evaluated using teacher drooling sizing (TDS), the drooling quotient and the Saxon test (ST). Any side-effects were also observed. Results There was no significant difference in the average TDS score, drooling quotient or ST score between the two groups before the intervention. After the intervention all of those measurements had decreased significantly, but there were still no significant differences between the two groups in any measurement at any time point. Conclusions Botulinum toxin type A injection under the guidance of ultrasound is accurate and safe. The injection of 10u is sufficient to relieve children′s sialorrhoea without serious side effects. |
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