乔会敏,詹海燕,吴冰洁,等.环境对雄性快速老化小鼠P8血促肾上腺皮质激素、皮质醇与睾酮浓度的影响[J].中华物理医学与康复杂志,2020,42(11):973-977
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| 环境对雄性快速老化小鼠P8血促肾上腺皮质激素、皮质醇与睾酮浓度的影响 |
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| DOI：10.3760/cma.j.issn.0254-1424.2020.11.003 |
| 中文关键词: 环境 快速老化小鼠 促肾上腺皮质激素 皮质醇 睾酮 |
| 英文关键词: Environment Adrenocorticotropic hormone Cortisol Testosterone |
| 基金项目:河北省卫生健康委员会医学科学研究重点课题（20120078） |
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| 中文摘要: |
| 目的 不同环境对雄性快速老化小鼠P8（SAMP8）血促肾上腺皮质激素（ACTH）、皮质醇和睾酮水平的影响。 方法 将雄性SAMP8小鼠30只随机分为丰富环境组、贫瘠环境组和标准环境组，每组10只，均在对应环境中生活8周。8周后采用放射免疫方法测定血ACTH、皮质醇和睾酮水平。 结果 饲养8周后，贫瘠组、丰富组和标准组血ACTH浓度分别为（60.54±16.22）pg/ml、（48.98±15.30）pg/ml和（28.49±8.24）pg/ml；血皮质醇浓度分别为（5.37±0.81）ng/ml、（4.09±0.92）ng/ml、（3.19±0.88）ng/ml；血睾酮浓度分别为（2.35±0.90）ng/ml、（7.07±1.57）ng/ml、（3.16±1.10）ng/ml。标准环境组小鼠的血ACTH水平和血皮质醇水平与贫瘠环境组比较，差异均有统计学意义(P<0.05)，标准环境组的血ACTH水平和血睾酮水平与丰富环境组比较，差异有统计学意义(P<0.05)，丰富环境组小鼠的血皮质醇水平和血睾酮水平与贫瘠环境组比较，差异有统计学意义(P<0.05)。 结论 贫瘠环境可促进SAMP8小鼠血ACTH分泌，皮质醇增多，并激活下丘脑-垂体-肾上腺（HPA）轴。丰富环境对SAMP8小鼠血ACTH的产生和血睾酮浓度的升高有促进作用，但对皮质醇的促进作用不明显。 |
| 英文摘要: |
| Objective To investigate any effect of different environments on the levels of adrenocorticotropic hormone (ACTH), cortisol and testosterone using SAMP8 senescence-accelerated mice. Methods Thirty SAMP8 mice were randomly divided into an enriched environment (EE) group, an impoverished environment (IE) group and a standard environment (SE) group, each of 10. The serum levels of ACTH, cortisol and testosterone were measured in all of the mice after they had lived in their respective environments for 8 weeks. Results The average ACTH concentrations of the IE, EE and SE groups were (60.54±16.22), (48.98±15.30) and (28.49±8.24)pg/ml respectively. The average cortisol concentrations were (5.37±0.81), (4.09±0.92) and (3.19±0.88)ng/ml. The average testosterone concentrations being (2.35±0.90), (7.07±1.57) and (3.16±1.10)ng/ml. The average ACTH and cortisol levels were significantly different between the SE and IE groups. The average ACTH and testosterone levels differed significantly between the SE and EE groups and between the EE and IE groups. Conclusions An impoverished environment can increase the secretion of ACTH and cortisol and activate the hypothalamic-pituitary-adrenal axis, at least in SAMP8 mice. An enriched environment can promote the secretion of ACTH and testosterone, but not that of cortisol. |
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