郭明霞，王学民，马舜尧，王明时.调制脉冲磁场对大鼠记忆保持和再现能力的影响及其机制[J].中华物理医学与康复杂志,2003,(2):.-
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| 调制脉冲磁场对大鼠记忆保持和再现能力的影响及其机制 |
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| DOI： |
| 中文关键词: 记忆能力 脉冲磁场 海马 突触 |
| 英文关键词: Memory ability Pulse magnetic field Hippocampus Synapse |
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| 中文摘要: |
| 目的探讨调制脉冲磁场对大鼠记忆保持及再现能力的影响及其作用机制。 方法采用改良“十”字迷宫法测试磁场对大鼠记忆行为的影响；通过电镜观察磁场对大鼠海马组织神经细胞形态的影响。 结果20 Hz调制脉冲磁场刺激后大鼠记忆再现能力明显降低（P<0.05），刺激后1 h大鼠记忆保持能力明显降低（P<0.05），刺激后24 h磁场对记忆保持的影响基本消失（P>0.05），磁场对记忆的影响因记忆内容而异。20 Hz调制脉冲磁场刺激后大鼠海马神经元突触形态发生变化。 结论脉冲磁场引起神经突触变化是其影响大鼠记忆能力的主要作用机制之一。 |
| 英文摘要: |
| Objective To explore the effect and the mechanism of modulated magnetic pulse fields on memory retention and retrieval ability of rats. MethodsThe influence of different pulsed magnetic fields on memory performance of rats was evaluated by using cross maze test, the morphological changes of neurons and nerve synapses in the hippocampus of rats were observed by the electronic microscopy. ResultsThe 20 Hz modulated-pulse magnetic field impaired the memory retrieval ability and the memory retention significantly after 1 hour of exposure of the rats to it (P<0.05), but the influence died down after 24 hours (P>0.05). These influences on nerve tissues were also observed in rats underwent the 10Hz modulated magnetic stimulation, manifested as an initial increase in ability of memory in the first 24 hours after the stimulation, but no significant difference from the control was found. The influence of magnetic fields on memory depended on what the rats remembered. ConclusionChanges in the nerve synapses may be a main factor of mechanisms of the influence of pulse magnetic fields on memory ability of rats. |
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