袁华，龙华，李玲.康复训练对脑梗死大鼠皮质S-100、GFAP和Nestin表达的影响[J].中华物理医学与康复杂志,2003,(9):.-
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| 康复训练对脑梗死大鼠皮质S-100、GFAP和Nestin表达的影响 |
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| DOI： |
| 中文关键词: 康复训练 脑梗死 皮质 S-100 胶质原纤维酸性蛋白 巢蛋白 |
| 英文关键词: Rehabilitation training Cerebral infarction Cortex S-100 GFAP Nestin |
| 基金项目:军队留学人员回国启动基金(No.97科训字116号) |
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| 中文摘要: |
| 目的研究康复功能训练后，脑梗死大鼠皮质S-100、胶质原纤维酸性蛋白（GFAP）和巢蛋白（Nestin）表达的变化。 方法60只SD大鼠制作脑梗死模型；24 h后随机分为康复组和制动组；康复组每天给予平衡、抓握、旋转、行走等功能训练，制动组置于网状笼内固定，另设对照组不经任何处理，各组在24 h和1，2，3，4周用免疫组化方法检测皮质中S-100、GFAP和Nestin表达。 结果康复组和制动组大鼠皮质梗死灶周围出现S-100、GFAP和Nestin阳性染色细胞，随时间延长反应增强，康复组反应明显较制动组强。 结论康复功能训练可激活大量的星形胶质细胞，改善神经元的内环境，保护神经元，促进其修复，有利于功能的恢复。 |
| 英文摘要: |
| Objective To study the effect of rehabilitation training on the expression of S-100, GFAP and Nestin in the cortex of cerebrally infarcted rats. MethodsSixty Sprague-Dawley rats were used. Experimental cerebral infarction was caused in all the rats. 24 hours after the infarction, all the rats were randomly divided into 3 groups: a rehabilitation group, an immobiliaztion group and a control group. The rats in the rehabilitation group were given balancing, grasping, rotating and walking exercises everyday, while those in the immobilization group were immobilized in cages. The rats in the control group was without any treatment. Immunohistochemical technique was used to detect the S-100, GFAP and Nestin expression at the time points of 24 hours, 1, 2, 3 and 4 weeks after infarction, respectively. ResultsS-100, GFAP and Nestin expression were found around the infarcted cortex. The response increased as the extension of the surviving time. The immunohistochemical reaction in rats in the rehabilitation group was stronger than that in the immobilization group. ConclusionRehabilitation training can activate astrocytes, which could improve the internal environment, protect the neurons and promote repairing of neuron. |
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