空气净化对老年2型糖尿病患者血浆内皮素-1的影响

汪涛; 张胜兰; 何虹; 王青; 郭志军; 韩文章

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汪涛，张胜兰，何虹，王青，郭志军，韩文章.空气净化对老年2型糖尿病患者血浆内皮素-1的影响[J].中华物理医学与康复杂志,2002,(1):.-

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空气净化对老年2型糖尿病患者血浆内皮素-1的影响

DOI：

中文关键词: 空气净化糖尿病血浆内皮素-1 超氧化物歧化酶谷胱甘肽过氧化物酶丙二醛

英文关键词: Air Purification Diabetes ET-1 SOD GSH-px MDA

基金项目:

作者	单位
汪涛，张胜兰，何虹，王青，郭志军，韩文章	266071山东青岛,济南军区青岛第一疗养院三科(汪涛、何虹、王青、郭志军、韩文章)；济南军区总医院内分泌科(张胜兰)

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中文摘要:

目的探讨空气净化对老年2型糖尿病患者血浆内皮素-1等的改善。方法老年2型糖尿病疗养员43例随机分为空气净化组(n=24)和对照组(n=19)。空气净化组所处的疗养室进行每日24 h空气净化，对照组患者住普通病房。两组均每隔1个月抽血检测血浆内皮素1、超氧化物歧化酶、谷胱甘酞过氧化物酶、丙二醛和心功能指标。结果实验组空气净化1个月后，内皮素-1、丙二醛由净化前的4.23±1.15pg/ml、4.58±0.44 mmol/L分别下降为3.41±1.28 pg/ml、4.13±0.34 mmol/L(P均<0.05)，超氧化物歧化酶、谷胱甘酞过氧化物酶由净化前的82.3±8.7 nU/ml、44.7±5.9 U/L分别上升为88.5±9.6 nU/ml、57.5±6.4 U/L，有效率分别为75%，75%，70.8%，66.7%。心功能指标也有明显的改善(P<0.05)。结论对老年2型糖尿病患者行空气净化治疗，能显著改善其血浆内皮素-1的含量、心功能和抗氧化能力。

英文摘要:

ObjectiveTo investigate the effect of air purification on changes of plasma levels of ET-1, SOD, GSH-px, and MDA in patients with type 2 diabetesMethodsThe living rooms of 24 patients with type 2 diabetes were purified with air cleaner (MKJ-800) once a day for 30 days, then the aforementioned parameters were assessed and compared with that obtained at the begining of hospitalization. In patients of the control group (N=19), who lived in the ordinary wards, the changes of these parameters were also evaluatedResultsThe average plasma levels of ET-1 and MDA of patients in the experimental group were markedly decreased (from 4.23±1.15 pg/ml to 3.14±1.28 pg/ml, and 4.58±0.44 mmol/L to 4.13±0.34 mmol/L, respectively), while the plasma levels of SOD and GSH-px were significantly increased. Evidence of improved cardiac function were also noted in these patients.ConclusionRoom air purification can decrease the ET-1, SOD, GSH-px and MDA content of plasma and improve the cardiac function of patients with type 2 diabetes

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