李明亮，高根德.体外冲击波治疗家兔股骨头坏死的实验研究[J].中华物理医学与康复杂志,2004,(11):
扫码阅读全文
|
| 体外冲击波治疗家兔股骨头坏死的实验研究 |
|
| |
| DOI： |
| 中文关键词: 体外冲击波 股骨头坏死 冷冻 激素 |
| 英文关键词: Extracorporeal shock wave Femoral head necrosis Freezing Hormone |
| 基金项目: |
|
| 摘要点击次数: 2146 |
| 全文下载次数: 2789 |
| 中文摘要: |
| 目的探讨体外冲击波对物理损伤型和激素型兔股骨头坏死的影响，并阐述其作用机理。 方法22只日本大耳白兔，按随机数字表分为冷冻致股骨头缺血性坏死组（A组）和激素致股骨头缺血性坏死组（B组），每组各11只，双后肢制造股骨头坏死模型。所有实验兔右后腿作为治疗侧，采用电压为12 kV，频率为60次/min，冲击量为1 000次的体外冲击波治疗；左后腿作为对照侧，不予治疗。分别于治疗后2，4和8周将兔处死，并拍摄X线片，切片后于光镜和电子显微镜下观察。 结果治疗后第8周X线片示实验兔治疗侧股骨头塌陷程度均比对照侧轻；治疗侧空骨陷窝率、血管数和成骨细胞计数与对照侧比较，差异均有统计学意义。 结论冲击波疗法对冷冻致股骨头缺血性坏死和激素致股骨头缺血性坏死均有较好疗效，其作用机制可能与冲击波治疗使血管再通或促进成骨细胞成骨有关。 |
| 英文摘要: |
| Objective To investigate the effect of extracorporeal shock wave (ESW) on physically- or hormonally-induced femoral head necrosis of rabbits, and to study the underlying mechanism. MethodsTwenty-two Japanese rabbits were randomly divided into two groups: group A and group B. Different methods were used for each group to establish the model of bilateral femoral head necrosis: freezing for group A and hormone injection for group B. The right hind limbs of all rabbits were used as the treatment side treated with ESW while the left hind limbs as control without any treatment. The rabbits were sacrificed at 2, 4, 8 weeks, respectively, after the treatment. X-ray, pathological and electron microscope examinations were adopted to observe the changes of the femoral head. ResultsAt the 8th week after ESW treatment, X-ray imaging showed less severe cave-in on the femoral head of the control side than that of the treatment side in both groups. The empty lacunae ratio, the number of the osteoblast and the blood vessels were significantly different between the treatment and the control sides, but not between the two groups. ConclusionESW is an effective treatment for the physically- and the hormonally-induced femoral head necrosis. The mechanism may include recanalization of the blocked vessel and promotion of the osteoblast growth. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
