注意缺陷多动障碍、精神发育迟滞及品行障碍患儿的脑干听觉反应临床研究

吴丽慧; 王德选; 林蔚; 王慧丽; 汤春萍; 留佩宁; 胡鸿文

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吴丽慧，王德选，林蔚，王慧丽，汤春萍，留佩宁，胡鸿文.注意缺陷多动障碍、精神发育迟滞及品行障碍患儿的脑干听觉反应临床研究[J].中华物理医学与康复杂志,2004,(6):

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注意缺陷多动障碍、精神发育迟滞及品行障碍患儿的脑干听觉反应临床研究

DOI：

中文关键词: 注意缺陷多动障碍精神发育迟滞品行障碍脑干听觉反应

英文关键词: Attention deficit and hyperactive disorder Mental retardation Conduct disorder Brainstem auditory responses

基金项目:浙江省教委资助项目(No.20010351)

作者	单位
吴丽慧，王德选，林蔚，王慧丽，汤春萍，留佩宁，胡鸿文	325003温州，浙江省温州医学院附属儿童医院儿保科

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中文摘要:

目的探讨注意缺陷多动障碍（ADHD）患儿在脑干听觉反应(ABR)检测中的特点。方法应用美国Nicolet Spirit脑电生理仪及Click短声刺激，测查37例ADHD、24例精神发育迟滞（MR）、22例品行障碍（CD）和30名正常儿童（NC）的ABR。结果ADHD组、MR组、CD组及NC组在绝对潜伏期波Ⅲ、波Ⅴ（Fz脑区），波Ⅲ（Pz脑区），绝对波幅波Ⅲ（Fz脑区），波Ⅴ（Pz脑区）上差异有显著性意义（P<0.05～0.01）。在Fz脑区，波Ⅴ绝对潜伏期上与NC组相比，ADHD组、MR组和CD组均延迟（P<0.01）；进一步分析MR又延迟于ADHD组和CD组。在Pz脑区上，ADHD组和MR组波Ⅲ绝对潜伏期均前移。绝对波幅上不论是波Ⅲ还是波Ⅴ，ADHD组、MR组和CD组均低于NC组（P<0.01），进一步分析，在Pz脑区上，ADHD组和MR组波Ⅴ绝对波幅又明显低于CD组（P<0.01）。结论ABR对临床辅助诊断ADHD和MR有参考价值。

英文摘要:

Objective To investigate the features of brainstem auditory responses (BAR) in patients with attention deficit and hyperactive disorder (ADHD), mental retardation and conduct disorder. MethodsBAR in children with ADHD (n=37), mental retardation (MR, n=24) and conduct disorder (CD, n=22), and in normal children (n=30) were measured by use of Nicolet Spirit electrophysiological instrument delivering stimulation of Clicks. ResultsThe absolute latencies (AL) of wave Ⅲ、Ⅴ recorded from Fz region (WⅢ、Ⅴ/Fz) and wave Ⅲ from Pz region (WⅢ/Pz) as well as the absolute amplitudes (AA) of WⅢ/Fz and WⅤ/Pz were significantly different (P<0.05) among ADHD, MR, CD, NC groups. Compared with those of NC group, the AL of WⅤ/Fz in ADHD, MR and CD groups were significantly delayed (P<0.01). The AL of WV/Fz was delayed in ADHD, CD and MR children as compared to that of the NC(P<0.01), with that of the MR more significant. The AL of WⅢ/Pz in ADHD、CD groups were shortened. Compared with those in NC group, the AA of WⅢ and WⅤin ADHD, MP, CD groups were significantly decreased (P<0.01). Further analysis showed that the AA of WⅤ/Pz in ADHD, MR groups were markedly decreased as compared to those in CD group (P<0.01). ConclusionBAR could be of help in the clinical diagnosis of ADHD and MR.

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