向毅，陈钢，王胜军，方勇军，蔡瑞君，邓亲恺.不同幅度脉冲膈肌起搏对兔膈肌SOD、MDA、总抗氧化能力的影响[J].中华物理医学与康复杂志,2004,(5):
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| 不同幅度脉冲膈肌起搏对兔膈肌SOD、MDA、总抗氧化能力的影响 |
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| DOI： |
| 中文关键词: 膈肌起搏 超氧化物歧化酶 丙二醛 总抗氧化能力 |
| 英文关键词: Diaphragm pacing Superoxide dismutase Malondialdehyde Total anti-oxidation capability |
| 基金项目:广东省自然科学基金项目（No.2002392） |
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| 摘要点击次数: 1970 |
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| 中文摘要: |
| 目的探讨不同幅度脉冲膈肌起搏（diaphragm pacing，DP）对新西兰大白兔膈肌的影响。 方法建立兔颈部DP模型，测定无起搏（A）组及脉冲幅度匀速增加（B）组、恒定（C）组、匀速减小（D）组起搏后膈肌组织SOD、MDA及T-AOC。 结果①DP后，B组较A组MDA含量增加，SOD及T-AOC减小（P>0.05）；②DP后，C组及D组较A组MDA含量增加，SOD及T-AOC减小（P<0.05）；③DP后，B组较C及D组MDA含量少，SOD及T-AOC活力强（P<0.05）。 结论①脉冲幅度匀速增加通过减少氧自由基的产生，抗氧化能力的干扰，可能减缓了膈肌疲劳（diaphragm failure，DF）的发生，②脉冲幅度匀速增加与脉冲幅度恒定和匀速减小相比，是一种更为合理的DP方式。 |
| 英文摘要: |
| Objective To explore the effect of various pulse amplitudes on the amount of MDA, SOD and the total anti-oxidation capacity (T-AOC) in the diaphragm of Zelanian rabbit after diaphragm pacing. MethodsTwenty-four rabbits were used for establishing the diaphragm pacing model and then divided into groups A, B, C and D. No diaphragm pacing (DP) was administered with group A, while pacing with gradual increasing, gradual decreasing and constant pulse amplitude were administered, respectively, in groups B, C and D. The concentration of MDA, the activity of SOD and T-AOC were examined. ResultsTwo hours of DP with gradual increasing pulse amplitude caused increase of the amount of MDA and decrease of SOD and T-AOC as compared with those without DP (P>0.05). Two hours of DP with both gradual decreasing and constant pulse amplitude caused increase of MDA and decrease of SOD and T-AOC (P<0.05) as compared with those without DP. DP with gradual decreasing or constant pulse amplitude exerted a significantly larger effect as regard to the increase of MDA and decrease of SOD and T-AOC (P<0.05) than with the gradual decreasing pulse amplitude. ConclusionDP with gradual increasing pulse amplitude might be able to decrease the incidence of diaphragm failure (DF) through decreasing oxygen-derived free radicals and maintain the anti-oxidation capability. |
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