冯春花，徐晓云，王悦，葛夏，李渊灵，金花，赵玫.轻度认知障碍的转化结局及其相关影响因素分析[J].中华物理医学与康复杂志,2016,38(2):108-112
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| 轻度认知障碍的转化结局及其相关影响因素分析 |
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| DOI： |
| 中文关键词: 认知障碍 转化 影响因素 |
| 英文关键词: Cognitive impairment Alzheimer′s disease |
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| 中文摘要: |
| 目的探讨轻度认知障碍(MCI)的转化结局及相关影响因素。 方法收集受试者124例，其中MCI患者75例（MCI组），阿尔茨海默病(AD)患者32例（AD组），认知正常（NC）受试者17例（NC组），对所有受试者行前瞻性队列研究，以NC组和AD组作为对照，随访（1.70±1.25）年，计算年转化率（APR），并对其影响因素进行Logistic回归分析。 结果随访结束后，MCI组受试者中转为AD的APR为5.25%，转为正常的APR为9.76%；NC组受试者中转为MCI的APR为6.91%。经Logistic回归分析发现，自我认知管理是MCI组受试者转为AD的保护因素；另外，自我认知管理、心脏疾病分别是认知功能好转的保护因素和危险因素，而高血脂和BMI＜24kg/m2是认知功能恶化的危险因素。 结论MCI是转为AD的高危因素，而自我认知管理可促进认知功能的好转，同时防治高血脂和心脏疾病、适当增加BMI可能延缓老年认知功能的恶化。 |
| 英文摘要: |
| Objective To investigate the progression of mild cognitive impairment (MCI) to Alzheimer′s disease (AD) and the factors influencing the related changes in cognitive ability. Methods Seventy-five subjects with mild cognitive impairment (the MCI group), 32 with Alzheimer′s disease (the AD group) and 17 others with normal cognition (the NC group) were recruited. The Montreal Cognitive Assessment (MOCA) and the Mini-mental State Examination (MMSE) were used to assess their cognitive ability. At the same time, relevant clinical information such as their general condition and past history of disease were recorded. The subjects were followed up for 20 months on average to evaluate their annual rates of progression (APRs), and logistic regression was used to highlight any influencing factors. ResultsBy the end of the follow-up, 9 of the 75 MCI subjects had progressed to AD, with an APR of 5.25%. Thirteen cases had recovered normal cognitive functioning (97.6 per 1,000 person-years). Also, 2 cases in the NC group (11.76%) developed MCI (69.1 per 1,000 person-years), but none of them had yet progressed to AD. Both hyperlipidemia and a body mass index (BMI) lower than 24 kg/m2 significantly predicted the deterioration of cognitive functioning. Heart disease was significantly correlated with cognitive improvement, and self-management of cognitive function was also a significant protective factor. ConclusionsPatients with MCI are at greater risk of developing AD than normal persons. Prevention and early treatment of hyperlipidemia as well as maintaining a normal BMI may delay the deterioration of cognitive functioning. Self-management of cognitive function can improve cognition. |
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